Department of Medicine, All India Institute of Medical Sciences, Bilaspur, Himachal Pradesh, India.
Department of Nephrology, All India Institute of Medical Sciences, Bilaspur, Himachal Pradesh, India.
Saudi J Kidney Dis Transpl. 2021 Sep-Oct;32(5):1220-1234. doi: 10.4103/1319-2442.344741.
Coronaviruses are ubiquitous pathogens and have caused epidemics in the recent past. Coupled with globalization, they have the potential to transform into the pandemic, as is the case of coronavirus disease 2019 (COVID-19). Primarily to start as a respiratory illness, they are known to cause systemic disease and affect many organ systems. Due to the lack of, universally proven, specific anti-viral therapy, the mainstay of treatment is "supportive care" and some of the patients afflicted with it, require intensive care and organ support for lungs and/or kidneys. Patients with the diseases of the kidney, particularly those on dialysis and kidney transplant recipients, are predisposed to the worst outcomes with COVID-19. It also leads to acute kidney injury, which is an important and independent determinant of prognosis in these patients. It also creates a huge demand for the delivery of renal replacement therapy. COVID-19 is an emerging and evolving disease, and so, it is important to understand the mechanism and management of kidney diseases in COVID-19.
冠状病毒是无处不在的病原体，在最近的过去曾引发过疫情。再加上全球化的影响，它们有可能像 2019 年冠状病毒病（COVID-19）那样演变成大流行。它们最初主要表现为呼吸道疾病，但已知会引起全身性疾病并影响许多器官系统。由于缺乏普遍证明有效的抗病毒治疗方法，治疗的主要方法是“支持性护理”，其中一些患者需要重症监护和肺/肾器官支持。患有肾脏疾病的患者，特别是那些接受透析和肾移植的患者，COVID-19 的预后最差。它还会导致急性肾损伤，这是这些患者预后的一个重要且独立的决定因素。这也对肾脏替代治疗的实施提出了巨大的需求。COVID-19 是一种新兴的不断发展的疾病，因此，了解 COVID-19 中的肾脏疾病的发病机制和治疗方法非常重要。
