Department UOC SITRA, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo Agostino Gemelli 8, 00168, Rome, Italy.
Haematology Unit, Oncology and Advanced Technology Department, Azienda USL-IRCCS Reggio Emilia, Reggio Emilia, Italy.
Int J Hematol. 2022 Aug;116(2):266-275. doi: 10.1007/s12185-022-03351-7. Epub 2022 May 9.
Although the effects of malnutrition on morbidity and mortality in adult patients undergoing allogeneic hematopoietic stem cell transplantation are clear, the relationship with quality of life (QOL) is less clear. The purpose of this study was to assess the relationship between malnutrition and QOL. A prospective observational study was conducted in 36 adult patients undergoing allogeneic hematopoietic stem cell transplantation. Adapted criteria of the Global Leadership Initiative on malnutrition have been used for the diagnosis of malnutrition in clinical settings. A cancer linear analog scale was used to assess QOL. Overall QOL at 14 days after allogeneic hematopoietic stem cell transplantation was 37.1 (95% CI 2.9-45.39) in patients without severe malnutrition, versus 16.0 (95% CI - 6.6 to 38.6) in patients with severe malnutrition (p = 0.05). At discharge, it was 48.0 (95% CI 38.4-57.6) versus 34.0 (95% CI 4.1-63.9) (p = 0.27). The results of our study suggest that patients with severe malnutrition at discharge tend to have worse QOL. A larger cohort of patients is required to confirm this hypothesis.
尽管营养不良对接受异基因造血干细胞移植的成年患者的发病率和死亡率的影响是明确的，但与生活质量（QOL）的关系尚不清楚。本研究旨在评估营养不良与 QOL 之间的关系。对 36 名接受异基因造血干细胞移植的成年患者进行了前瞻性观察研究。在临床环境中，使用全球营养不良领导力倡议的适应标准来诊断营养不良。使用癌症线性模拟量表来评估 QOL。在异基因造血干细胞移植后 14 天，无严重营养不良的患者的总体 QOL 为 37.1（95%CI 2.9-45.39），而严重营养不良的患者为 16.0（95%CI - 6.6 至 38.6）（p=0.05）。出院时，前者为 48.0（95%CI 38.4-57.6），后者为 34.0（95%CI 4.1-63.9）（p=0.27）。我们的研究结果表明，出院时患有严重营养不良的患者的 QOL 往往更差。需要更大的患者队列来证实这一假设。
