Double-blind comparative trial of standard (commercial) and antibody-affinity-purified tetanus toxoid vaccines.
作者信息
Leen C L, Barclay G R, McClelland D B, Shepherd W M, Langford D T
出版信息
J Infect. 1987 Mar;14(2):119-24. doi: 10.1016/s0163-4453(87)91877-9.
PMID:3553336
Abstract
Tetanus toxoid purified by antibody-affinity chromatography, was compared with conventionally purified material in a double-blind trial in 205 healthy blood donors. There was neither any difference in immunogenicity as assessed by enzyme-linked immunoassay nor in side-reactions between the two vaccines. This study confirms that side-reactions to tetanus toxoid are not eliminated by purifying it.
摘要
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