Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt; Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo 11231, Egypt.
Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt.
Pathol Res Pract. 2023 Nov;251:154880. doi: 10.1016/j.prp.2023.154880. Epub 2023 Oct 11.
In recent years, microRNAs (miRNAs) have gained increased attention from researchers around the globe. Although it is twenty nucleotides long, it can modulate several gene targets simultaneously. Their mal expression is a signature of various pathologies, and they provide the foundation to elucidate the molecular mechanisms of each pathology. Among the debilitating central nervous system (CNS) disorders with a growing prevalence globally is the multiple sclerosis (MS). Moreover, the diagnosis of MS is challenging due to the lack of disease-specific biomarkers, and the diagnosis mainly depends on ruling out other disabilities. MS could adversely affect patients' lives through its progression, and only symptomatic treatments are available as therapeutic options, but an exact cure is yet unavailable. Consequently, this review hopes to further the study of the biological features of miRNAs in MS and explore their potential as a therapeutic target.
近年来，微小 RNA（miRNA）引起了全球研究人员的广泛关注。虽然 miRNA 只有 20 个核苷酸长，但它可以同时调节多个基因靶点。它们的异常表达是各种病理的特征，并为阐明每种病理的分子机制提供了基础。在全球发病率不断上升的衰弱性中枢神经系统（CNS）疾病中，多发性硬化症（MS）就是其中之一。此外，由于缺乏疾病特异性生物标志物，MS 的诊断具有挑战性，主要依赖于排除其他残疾。MS 可能会通过其进展而对患者的生活产生不利影响，并且作为治疗选择，仅提供对症治疗，但是仍然没有确切的治愈方法。因此，本综述希望进一步研究 miRNA 在 MS 中的生物学特征，并探索其作为治疗靶标的潜力。
