中脑胆碱能神经元发出负反馈信号以促进行为灵活性。
Midbrain cholinergic neurons signal negative feedback to promote behavioral flexibility.
机构信息
Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ, USA.
Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ, USA.
出版信息
Trends Neurosci. 2022 Jul;45(7):502-503. doi: 10.1016/j.tins.2022.04.005. Epub 2022 May 7.
Abstract
Cholinergic neurons of the pedunculopontine nucleus (PPN) are relevant for adaptive behavior. In a recent study, Ruan et al. revealed that PPN cholinergic neurons signal negative feedback during reward omission after contingency changes, which is necessary for switching to new behavioral strategies.
摘要
被盖核中的胆碱能神经元与适应性行为有关。在最近的一项研究中，Ruan 等人揭示了在关联变化后奖励缺失期间，被盖核中的胆碱能神经元会发出负反馈信号，这对于切换到新的行为策略是必要的。
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