Department of Nutrition, Institute for Global Nutrition, University of California, Davis, CA, USA.
Helen Keller International, Washington, DC, USA.
Eur J Nutr. 2022 Oct;61(7):3423-3435. doi: 10.1007/s00394-022-02890-3. Epub 2022 May 9.
To assess the effects of intervention with a daily multiple micronutrient powder (MNP) on thiamine, riboflavin, folate, and B status among young Laotian children.
Children (n = 1704) aged 6-23 mo, participating in a double-blind placebo-controlled randomized trial were individually randomized to receive daily either MNP (containing 0.5 mg of thiamine, 0.5 mg riboflavin, 150 μg folic acid, and 0.9 μg vitamin B along with 11 other micronutrients) or placebo and followed for ~ 36 weeks. In a randomly selected sub-sample of 260 children, erythrocyte thiamine diphosphate (eThDP), plasma folate and B concentrations, and erythrocyte glutathione reductase activation coefficient (EGRac; riboflavin biomarker) were assessed at baseline and endline.
There was no treatment effect on endline eThDP concentrations (110.6 ± 8.9 nmol/L in MNP vs. 109.4 ± 8.9 nmol/L in placebo group; p = 0.924), EGRac (1.46 ± 0.3 vs. 1.49 ± 0.3; p = 0.184) and B concentrations (523.3 ± 24.6 pmol/L vs. 515.9 ± 24.8 pmol/L; p = 0.678). Likewise, the prevalence of thiamine, riboflavin, and B deficiencies did not differ significantly between the two groups. However, endline folate concentration was significantly higher in the MNP compared to the placebo group (28.2 ± 0.8 nmol/L vs 19.9 ± 0.8 nmol/L, respectively; p < 0.001), and correspondingly, the prevalence of folate deficiency was significantly lower in the MNP group (1.6% vs 17.4%; p = 0.015).
Compared to a placebo, daily MNP for 9 months increased only folate but not thiamine, riboflavin, or B status in young Laotian children.
The trial was registered at www.
gov (NCT02428647) on April 29 2015.
评估每日多种微量营养素粉（MNP）干预对老挝幼儿体内硫胺素、核黄素、叶酸和 B 族维生素状况的影响。
1704 名年龄在 6-23 个月的儿童参与了一项双盲安慰剂对照随机试验，他们被单独随机分为每日接受 MNP（含 0.5mg 硫胺素、0.5mg 核黄素、150μg 叶酸和 0.9μg 维生素 B 以及其他 11 种微量营养素）或安慰剂，并随访约 36 周。在 260 名儿童的随机子样本中，在基线和终点评估了红细胞硫胺素二磷酸（eThDP）、血浆叶酸和 B 浓度以及红细胞谷胱甘肽还原酶激活系数（EGRac；核黄素生物标志物）。
MNP 组（110.6±8.9nmol/L）与安慰剂组（109.4±8.9nmol/L）的终点 eThDP 浓度（110.6±8.9nmol/L）、EGRac（1.46±0.3vs.1.49±0.3）和 B 浓度（523.3±24.6pmol/Lvs.515.9±24.8pmol/L）均无治疗效果（p=0.924）。同样，两组之间的硫胺素、核黄素和 B 缺乏症的患病率也无显著差异。然而，MNP 组的终点叶酸浓度明显高于安慰剂组（分别为 28.2±0.8nmol/L 和 19.9±0.8nmol/L，p<0.001），相应地，MNP 组的叶酸缺乏症患病率也明显较低（1.6%vs.17.4%，p=0.015）。
与安慰剂相比，9 个月的每日 MNP 仅增加了叶酸，而未增加老挝幼儿的硫胺素、核黄素或 B 族维生素状况。
该试验于 2015 年 4 月 29 日在 www.clinicaltrials.gov 上注册（NCT02428647）。
