Ishibashi Y, Kaufman H E, Kagawa S
J Med Vet Mycol. 1986 Dec;24(6):437-44.
To compare the development of keratomycosis after central or peripheral corneal inoculation, Candida albicans was inoculated in the central portion of the right eyes of 24 rabbits and in the peripheral cornea, near the limbus, of the left eyes in the same rabbits. The clinical scores of the central ulcers were significantly higher than those of the peripheral lesions. On the 12th day after inoculation, all cultures of corneal specimens from the peripheral ulcers were negative, while 10 cultures from the central ulcers were still positive. Histopathologic examination showed earlier and more extensive inflammatory reactions in eyes with peripheral lesions, compared with those in eyes with central lesions.
为比较中央或周边角膜接种后角膜真菌病的发展情况，将白色念珠菌接种于24只家兔右眼的中央部分以及同一只家兔左眼靠近角膜缘的周边角膜。中央溃疡的临床评分显著高于周边病变。接种后第12天，周边溃疡角膜标本的所有培养物均为阴性，而中央溃疡的10份培养物仍为阳性。组织病理学检查显示，与中央病变的眼睛相比，周边病变的眼睛炎症反应更早且更广泛。
