Ishibashi Y, Matsumoto Y
Sabouraudia. 1984;22(4):323-30.
Oral ketoconazole (100 mg daily for 3 weeks) markedly reduced the severity of experimental Candida albicans keratitis in a group of 10 rabbits. Clinical scores of affected eyes were statistically significantly lower in the treated group than in a control group of 10 untreated rabbits. All cultures of corneal scrapings in the treated eyes were negative on the 15th day after the inoculation, whilst three positive cultures were still obtained on the 21st day in the control animals. Histopathological examination of eyes from treated and untreated rabbits showed great differences in the intensity of inflammatory changes in the two groups.
口服酮康唑（每日100毫克，共3周）显著减轻了一组10只兔子实验性白色念珠菌角膜炎的严重程度。治疗组患眼的临床评分在统计学上显著低于10只未治疗兔子的对照组。接种后第15天，治疗组患眼角膜刮片的所有培养物均为阴性，而对照组动物在第21天仍有3份培养物呈阳性。对治疗组和未治疗组兔子的眼睛进行组织病理学检查，结果显示两组炎症变化的强度存在很大差异。
