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结膜下注射咪康唑对兔实验性念珠菌性角膜炎的治疗效果。

The effects of subconjunctival miconazole in the treatment of experimental Candida keratitis in rabbits.

作者信息

Ishibashi Y, Kaufman H E

出版信息

Arch Ophthalmol. 1985 Oct;103(10):1570-3. doi: 10.1001/archopht.1985.01050100146038.

DOI:10.1001/archopht.1985.01050100146038
PMID:3901987
Abstract

Subconjunctival miconazole (1.2 mg/day for three weeks) produced a marked clinical improvement in the ocular lesions produced by inoculation with Candida albicans in a group of ten rabbits. Clinical scores of affected eyes were significantly lower in this treated group than in a control group of ten untreated rabbits. All cultures of corneal scrapings were negative on the 15th day after inoculation in the treated group, while three cultures were still positive at the end of the experiment (day 21) in the control group. Histopathologic examination showed considerably less-severe inflammatory changes in the eyes of treated animals compared with those of control animals.

摘要

结膜下注射咪康唑(1.2毫克/天,共三周)使一组十只兔子接种白色念珠菌后产生的眼部病变有了显著的临床改善。该治疗组中受影响眼睛的临床评分明显低于十只未治疗兔子的对照组。治疗组接种后第15天所有角膜刮片培养均为阴性,而对照组在实验结束时(第21天)仍有三份培养为阳性。组织病理学检查显示,与对照动物相比,治疗动物眼睛的炎症变化严重程度明显减轻。

相似文献

1
The effects of subconjunctival miconazole in the treatment of experimental Candida keratitis in rabbits.结膜下注射咪康唑对兔实验性念珠菌性角膜炎的治疗效果。
Arch Ophthalmol. 1985 Oct;103(10):1570-3. doi: 10.1001/archopht.1985.01050100146038.
2
Intravenous miconazole therapy for experimental keratomycosis in rabbits.静脉注射咪康唑治疗兔实验性角膜真菌病
Sabouraudia. 1985 Feb;23(1):55-61. doi: 10.1080/00362178585380091.
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Oral ketoconazole therapy for experimental candida albicans keratitis in rabbits.口服酮康唑治疗兔实验性白色念珠菌角膜炎
Sabouraudia. 1984;22(4):323-30.
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Anomalous effect of subconjunctival miconazole on Candida albicans keratitis in rabbits.结膜下注射咪康唑对兔白色念珠菌角膜炎的异常作用。
Am J Ophthalmol. 1991 Nov 15;112(5):562-6. doi: 10.1016/s0002-9394(14)76859-x.
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Topical ketoconazole for experimental Candida keratitis in rabbits.
Am J Ophthalmol. 1986 Oct 15;102(4):522-6. doi: 10.1016/0002-9394(86)90084-x.
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Differences in development of keratomycosis after Candida inoculation in the central and peripheral cornea.念珠菌接种于中央角膜和周边角膜后角膜真菌病发展情况的差异。
J Med Vet Mycol. 1986 Dec;24(6):437-44.
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Efficacy and safety of extemporaneously prepared miconazole eye drops in Candida albicans-induced keratomycosis.临时配制的咪康唑滴眼液治疗白色念珠菌性角膜真菌病的疗效和安全性。
Int Ophthalmol. 2018 Oct;38(5):2089-2100. doi: 10.1007/s10792-017-0707-z. Epub 2017 Sep 12.
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Corneal biopsy in the diagnosis of keratomycosis.角膜活检在角膜真菌病诊断中的应用
Am J Ophthalmol. 1986 Mar 15;101(3):288-93. doi: 10.1016/0002-9394(86)90821-4.
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Contact lens-induced infection--a new model of Candida albicans keratitis.隐形眼镜引起的感染——白色念珠菌角膜炎的一种新模型。
Invest Ophthalmol Vis Sci. 1999 Jun;40(7):1607-11.
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[Subconjunctival miconazole for Candida keratitis in rabbits].
Nippon Ganka Gakkai Zasshi. 1984 Mar;88(3):580-5.

引用本文的文献

1
The pathogenicities of Cylindrocarpon tonkinense and Fusarium solani in the rabbit cornea.东京柱孢霉和茄病镰刀菌在兔角膜中的致病性。
Mycopathologia. 1986 Jun;94(3):145-52. doi: 10.1007/BF00454592.
2
Topical fluconazole for experimental candida keratitis in rabbits.局部应用氟康唑治疗兔实验性念珠菌性角膜炎
Br J Ophthalmol. 1990 Jan;74(1):40-2. doi: 10.1136/bjo.74.1.40.