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Perspective on automated drug screening using the mutant zebrafish line.

作者信息

Oprişoreanu Ana-Maria

机构信息

Center for Regenerative Therapies Dresden (CRTD), TU Dresden, Dresden, Germany.

出版信息

Neural Regen Res. 2022 Nov;17(11):2437-2438. doi: 10.4103/1673-5374.335795.

DOI:10.4103/1673-5374.335795
PMID:35535889
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9120713/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1df4/9120713/24c8c07f7313/NRR-17-2437-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1df4/9120713/24c8c07f7313/NRR-17-2437-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1df4/9120713/24c8c07f7313/NRR-17-2437-g001.jpg

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本文引用的文献

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Advances of Zebrafish in Neurodegenerative Disease: From Models to Drug Discovery.斑马鱼在神经退行性疾病中的研究进展:从模型到药物发现
Front Pharmacol. 2021 Jul 14;12:713963. doi: 10.3389/fphar.2021.713963. eCollection 2021.
2
Automated in vivo drug screen in zebrafish identifies synapse-stabilising drugs with relevance to spinal muscular atrophy.在斑马鱼体内进行的自动化药物筛选,鉴定出了与脊髓性肌萎缩症相关的稳定突触的药物。
Dis Model Mech. 2021 Apr 1;14(4). doi: 10.1242/dmm.047761. Epub 2021 Apr 26.
3
Interaction of Axonal Chondrolectin with Collagen XIXa1 Is Necessary for Precise Neuromuscular Junction Formation.
轴索软骨粘连蛋白与胶原 XIXa1 的相互作用对于精确的神经肌肉接头形成是必要的。
Cell Rep. 2019 Oct 29;29(5):1082-1098.e10. doi: 10.1016/j.celrep.2019.09.033.
4
Bi-allelic Variants in DYNC1I2 Cause Syndromic Microcephaly with Intellectual Disability, Cerebral Malformations, and Dysmorphic Facial Features.DYNC1I2 中的双等位基因突变导致伴有智力障碍、脑畸形和面部畸形特征的综合征性小头畸形。
Am J Hum Genet. 2019 Jun 6;104(6):1073-1087. doi: 10.1016/j.ajhg.2019.04.002. Epub 2019 May 9.
5
An automated high-resolution in vivo screen in zebrafish to identify chemical regulators of myelination.一种在斑马鱼体内进行自动化高分辨率筛选的方法,用于鉴定髓鞘形成的化学调节剂。
Elife. 2018 Jul 6;7:e35136. doi: 10.7554/eLife.35136.
6
Chondrolectin affects cell survival and neuronal outgrowth in in vitro and in vivo models of spinal muscular atrophy.软骨凝集素影响脊髓性肌萎缩症的体外和体内模型中的细胞存活和神经元生长。
Hum Mol Genet. 2014 Feb 15;23(4):855-69. doi: 10.1093/hmg/ddt477. Epub 2013 Sep 25.
7
Chondrolectin mediates growth cone interactions of motor axons with an intermediate target.软骨凝集素介导运动轴突与中间靶标的生长锥相互作用。
J Neurosci. 2012 Mar 28;32(13):4426-39. doi: 10.1523/JNEUROSCI.5179-11.2012.
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Identification of novel spinal cholinergic genetic subtypes disclose Chodl and Pitx2 as markers for fast motor neurons and partition cells.新型脊髓胆碱能基因亚型的鉴定揭示Chodl和Pitx2作为快速运动神经元和分隔细胞的标志物。
J Comp Neurol. 2010 Jun 15;518(12):2284-304. doi: 10.1002/cne.22332.
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