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本文引用的文献

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Marked Mild Cognitive Deficits in Humanized Mouse Model of Alzheimer's-Type Tau Pathology.阿尔茨海默病型 Tau 病理的人源化小鼠模型中存在明显的轻度认知缺陷。
Front Behav Neurosci. 2021 May 21;15:634157. doi: 10.3389/fnbeh.2021.634157. eCollection 2021.
2
Model organism development and evaluation for late-onset Alzheimer's disease: MODEL-AD.迟发性阿尔茨海默病的模式生物开发与评估:MODEL-AD
Alzheimers Dement (N Y). 2020 Nov 23;6(1):e12110. doi: 10.1002/trc2.12110. eCollection 2020.
3
The behavioural and neuropathologic sexual dimorphism and absence of MIP-3α in tau P301S mouse model of Alzheimer's disease.阿尔茨海默病tau P301S 小鼠模型中的行为和神经病理学性别二态性以及 MIP-3α 的缺失。
J Neuroinflammation. 2020 Feb 24;17(1):72. doi: 10.1186/s12974-020-01749-w.
4
Factors other than hTau overexpression that contribute to tauopathy-like phenotype in rTg4510 mice.导致 rTg4510 小鼠出现类似 tau 病表型的除 hTau 过表达以外的因素。
Nat Commun. 2019 Jun 6;10(1):2479. doi: 10.1038/s41467-019-10428-1.
5
New insights into the role of TREM2 in Alzheimer's disease.对 TREM2 在阿尔茨海默病中的作用的新认识。
Mol Neurodegener. 2018 Dec 20;13(1):66. doi: 10.1186/s13024-018-0298-9.
6
Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease: A Meta-analysis.载脂蛋白E基因型与阿尔茨海默病的性别风险因素:一项荟萃分析。
JAMA Neurol. 2017 Oct 1;74(10):1178-1189. doi: 10.1001/jamaneurol.2017.2188.
7
P301S mutant human tau transgenic mice manifest early symptoms of human tauopathies with dementia and altered sensorimotor gating.携带 P301S 突变的人类 tau 转基因小鼠表现出人类 tau 病的早期症状,包括痴呆和感觉运动门控改变。
PLoS One. 2011;6(6):e21050. doi: 10.1371/journal.pone.0021050. Epub 2011 Jun 15.
8
Sex differences in β-amyloid accumulation in 3xTg-AD mice: role of neonatal sex steroid hormone exposure.3xTg-AD 小鼠β-淀粉样蛋白积累的性别差异:新生儿性激素暴露的作用。
Brain Res. 2010 Dec 17;1366:233-45. doi: 10.1016/j.brainres.2010.10.009. Epub 2010 Oct 8.
9
Impact of gender differences on the outcome of Alzheimer's disease.性别差异对阿尔茨海默病结局的影响。
Dement Geriatr Cogn Disord. 2010;30(2):147-54. doi: 10.1159/000318842. Epub 2010 Aug 21.
10
Transcription-dependent silencing of inducible convergent transgenes in transgenic mice.转录依赖性沉默诱导的转基因小鼠中的共转化基因。
Epigenetics Chromatin. 2010 Jan 19;3(1):3. doi: 10.1186/1756-8935-3-3.

Modeling Alzheimer's disease: considerations for a better translational and replicable mouse model.

作者信息

Cho Joshua D, Yang Mu, Santa-Maria Ismael

机构信息

Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology & Cell Biology, Columbia University, New York, NY, USA.

The Mouse NeuroBehavior Core. Institute for Genomic Medicine, Columbia University, New York, NY, USA.

出版信息

Neural Regen Res. 2022 Nov;17(11):2448-2449. doi: 10.4103/1673-5374.335787.

DOI:10.4103/1673-5374.335787
PMID:35535894
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9120700/
Abstract
摘要