针刺刺激引起体感皮层的神经元和星形胶质细胞激活。
neuronal and astrocytic activation in somatosensory cortex by acupuncture stimuli.
作者信息
Chang Xiao-Yue, Chen Kai, Cheng Tong, Lai Pui To, Zhang Li, So Kwok-Fai, Yang Edward S
机构信息
Key Laboratory of CNS Regeneration (Minstry of Education), Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, Guangdong Province; Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong Special Administrative Region, China.
Key Laboratory of CNS Regeneration (Minstry of Education), Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, Guangdong Province, China.
出版信息
Neural Regen Res. 2022 Nov;17(11):2526-2529. doi: 10.4103/1673-5374.339003.
Acupuncture is a medical treatment that has been widely practiced in China for over 3000 years, yet the neural mechanisms of acupuncture are not fully understood. We hypothesized that neurons and astrocytes act independently and synergistically under acupuncture stimulation. To investigate this, we used two-photon in vivo calcium recording to observe the effects of acupuncture stimulation at ST36 (Zusanli) in mice. Acupuncture stimulation in peripheral acupoints potentiated calcium signals of pyramidal neurons and astrocytes in the somatosensory cortex and resulted in late-onset calcium transients in astrocytes. Chemogenetic inhibition of neurons augmented the astrocytic activity. These findings suggest that acupuncture activates neuronal and astrocytic activity in the somatosensory cortex and provide evidence for the involvement of both neurons and astrocytes in acupuncture treatment.
针灸是一种在中国已广泛应用了3000多年的医学疗法，然而针灸的神经机制尚未完全被理解。我们推测在针刺刺激下神经元和星形胶质细胞会独立发挥作用并协同作用。为了对此进行研究，我们使用双光子活体钙记录来观察针刺刺激小鼠足三里穴（ST36）的效果。外周穴位的针刺刺激增强了体感皮层中锥体神经元和星形胶质细胞的钙信号，并导致星形胶质细胞出现延迟性钙瞬变。对神经元进行化学遗传学抑制增强了星形胶质细胞的活性。这些发现表明针灸激活了体感皮层中的神经元和星形胶质细胞活性，并为神经元和星形胶质细胞都参与针灸治疗提供了证据。
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