无法嗅到病毒：SARS-CoV-2、染色质组织和嗅觉丧失。
Can't smell the virus: SARS-CoV-2, chromatin organization, and anosmia.
机构信息
Department of Genetics, The Alexander Silberman Institute for Life Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Jerusalem 9190401, Israel; The Edmond and Lily Safra Center for Brain Sciences (ELSC), The Hebrew University of Jerusalem, Edmond J. Safra Campus, Jerusalem 9190401, Israel.
Department of Genetics, The Alexander Silberman Institute for Life Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Jerusalem 9190401, Israel; The Edmond and Lily Safra Center for Brain Sciences (ELSC), The Hebrew University of Jerusalem, Edmond J. Safra Campus, Jerusalem 9190401, Israel.
出版信息
Dev Cell. 2022 May 9;57(9):1081-1082. doi: 10.1016/j.devcel.2022.04.015.
Anosmia, or loss of smell, is strongly associated with SARS-CoV-2 infection in humans, but the underlying mechanism remains obscure. In a recent Cell study, Zazhytska et al. (2022) report non-cell-autonomous disruption of long-range genomic interactions of olfactory receptor genes in response to SARS-CoV-2 infection, and these interactions remain disrupted long after virus clearance.
嗅觉丧失，又称失嗅，与人类感染 SARS-CoV-2 强烈相关，但潜在机制尚不清楚。在最近的一项《Cell》研究中，Zazhytska 等人（2022 年）报告称，SARS-CoV-2 感染会导致嗅觉受体基因的长程基因组相互作用发生非细胞自主破坏，而且这些相互作用在病毒清除后很长时间仍保持破坏状态。
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