From the Hayashi Eye Hospital, Fukuoka, Japan (Hirata, Mine, Hayashi); Department of Anatomy, Kurume University School of Medicine, Kurume, Japan (Hirata).
J Cataract Refract Surg. 2022 Jul 1;48(7):844-849. doi: 10.1097/j.jcrs.0000000000000967.
To determine morphological changes in the lens capsule with aging.
Hayashi Eye Hospital, Fukuoka, Japan.
Cross-sectional study.
25 eyes from the older patient group (aged 80 years or older) and 25 eyes from the younger patient group (aged 65 years or younger) who were diagnosed with cataract and indicated for surgery were included in the study. After continuous curvilinear capsulorhexis, the anterior lens capsule was collected, immediately fixed, and processed for electron microscopy analysis. Backscattered electron images of the cross-section of the anterior lens capsule were observed under a scanning electron microscope. The ultrastructure of the anterior lens capsule was observed and compared between the groups. Factors associated with the occurrence of the lamellar structure were also identified, with the presence or absence of a lamellar structure as an objective variable and preoperative clinical characteristics as the explanatory variables.
50 eyes of 50 patients were included. In the younger patient group, 20 eyes (80%) had a homogeneous lens capsule, whereas 5 eyes had lamellar structures. By contrast, in the older patient group, 5 eyes had homogeneous structures, while the remaining 20 eyes (80%) had lamellar structures. 1 eye showed capsular delamination. The only significant factor for the occurrence of lamellar structures was age group ( P < .01, nominal logistic regression analysis).
Lamellar structures appear in the anterior capsule during aging. The appearance of lamellar structures indicates fragility of the lens capsule, which may, in turn, lead to capsular delamination or lens dislocation in some cases.
研究晶状体囊随年龄增长发生的形态变化。
日本福冈市林眼科医院。
横断面研究。
研究纳入了 25 只年龄较大患者组（80 岁及以上）和 25 只年龄较小患者组（65 岁及以下）的患眼，这些患眼均被诊断为白内障并需要手术。连续环形撕囊后，采集前晶状体囊，立即固定，并进行电子显微镜分析。在扫描电子显微镜下观察前晶状体囊横截面的背散射电子像。观察两组间前晶状体囊的超微结构，并比较其差异。将是否存在层状结构作为因变量，以术前临床特征作为自变量，确定与层状结构发生相关的因素。
50 例 50 只眼纳入研究。在年龄较小的患者组中，20 只眼（80%）的晶状体囊呈均一结构，5 只眼存在层状结构。相比之下，在年龄较大的患者组中，5 只眼的晶状体囊呈均一结构，而其余 20 只眼（80%）存在层状结构。1 只眼出现了囊膜分层。发生层状结构的唯一显著因素是年龄组（P<.01，名义逻辑回归分析）。
层状结构在前晶状体囊随年龄增长的过程中出现。层状结构的出现表明晶状体囊易碎，这可能导致在某些情况下囊膜分层或晶状体脱位。
