炎症性合并症：训练还是不训练？

Inflammatory comorbidities: to train or not to train?

作者信息

Bobba Suhas, Khader Shabaana A

机构信息

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

出版信息

Trends Immunol. 2022 Jun;43(6):420-422. doi: 10.1016/j.it.2022.04.005. Epub 2022 May 8.

DOI:10.1016/j.it.2022.04.005

PMID:35537982

Abstract

Inflammatory stimuli reprogram innate immune cells to generate rigorous responses to future challenge with heterologous stimuli through trained immunity. Li et al. show that training of hematopoietic stem cells (HSCs) in the bone marrow primes cells to generate more inflammatory myeloid progeny and, thereby, mechanistically links inflammatory comorbidities.

摘要

炎症刺激通过训练免疫对先天免疫细胞进行重编程，使其对未来异源刺激的挑战产生强烈反应。李等人表明，对骨髓中的造血干细胞（HSC）进行训练能使细胞产生更多的炎性髓系后代，从而在机制上连接了炎症合并症。