Acta Biochim Biophys Sin (Shanghai). 2022 Mar 25;54(3):279-291. doi: 10.3724/abbs.2022006.
With the development of precision medicine, the efficiency of tumor treatment has been significantly improved. More attention has been paid to targeted therapy and immunotherapy as the key to precision treatment of cancer. Targeting epidermal growth factor receptor (EGFR) has become one of the most important targeted treatments for various cancers. Comparing with traditional chemotherapy drugs, targeting EGFR is highly selective in killing tumor cells with better safety, tolerability and less side effect. In addition, tumor immunotherapy has become the fourth largest tumor therapy after surgery, radiotherapy and chemotherapy, especially immune checkpoint inhibitors. However, these treatments still produce a certain degree of drug resistance. Non-coding RNAs (ncRNAs) were found to play a key role in carcinogenesis, treatment and regulation of the efficacy of anticancer drugs in the past few years. Therefore, in this review, we aim to summarize the targeted treatment of cancers and the functions of ncRNAs in cancer treatment.
随着精准医学的发展，肿瘤治疗的效率得到了显著提高。靶向治疗和免疫治疗作为癌症精准治疗的关键受到了更多的关注。针对表皮生长因子受体（EGFR）已成为各种癌症最重要的靶向治疗方法之一。与传统的化疗药物相比，针对 EGFR 的治疗方法在杀死肿瘤细胞方面具有高度的选择性，具有更好的安全性、耐受性和更少的副作用。此外，肿瘤免疫疗法已成为继手术、放疗和化疗之后的第四大肿瘤治疗方法，尤其是免疫检查点抑制剂。然而，这些治疗方法仍然会产生一定程度的耐药性。在过去的几年中，人们发现非编码 RNA（ncRNAs）在癌症的发生、治疗以及抗癌药物疗效的调节中起着关键作用。因此，在这篇综述中，我们旨在总结癌症的靶向治疗以及 ncRNAs 在癌症治疗中的作用。
