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原核生物抗病毒武器库的系统和定量分析。

Systematic and quantitative view of the antiviral arsenal of prokaryotes.

机构信息

Université de Paris, IAME, UMR 1137, INSERM, Paris, France.

SEED, U1284, INSERM, Université de Paris, Paris, France.

出版信息

Nat Commun. 2022 May 10;13(1):2561. doi: 10.1038/s41467-022-30269-9.

DOI:10.1038/s41467-022-30269-9
PMID:35538097
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9090908/
Abstract

Bacteria and archaea have developed multiple antiviral mechanisms, and genomic evidence indicates that several of these antiviral systems co-occur in the same strain. Here, we introduce DefenseFinder, a tool that automatically detects known antiviral systems in prokaryotic genomes. We use DefenseFinder to analyse 21000 fully sequenced prokaryotic genomes, and find that antiviral strategies vary drastically between phyla, species and strains. Variations in composition of antiviral systems correlate with genome size, viral threat, and lifestyle traits. DefenseFinder will facilitate large-scale genomic analysis of antiviral defense systems and the study of host-virus interactions in prokaryotes.

摘要

细菌和古菌已经开发出多种抗病毒机制，基因组证据表明，其中一些抗病毒系统存在于同一菌株中。在这里，我们引入了 DefenseFinder，这是一种自动检测原核基因组中已知抗病毒系统的工具。我们使用 DefenseFinder 分析了 21000 个完全测序的原核基因组，发现抗病毒策略在门、种和菌株之间有很大差异。抗病毒系统组成的变化与基因组大小、病毒威胁和生活方式特征有关。DefenseFinder 将促进抗病毒防御系统的大规模基因组分析以及原核生物中宿主-病毒相互作用的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e8d/9090908/9aa1dc8dec9e/41467_2022_30269_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e8d/9090908/bedf66c80350/41467_2022_30269_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e8d/9090908/aaab79790947/41467_2022_30269_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e8d/9090908/68f1aa8ca596/41467_2022_30269_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e8d/9090908/9aa1dc8dec9e/41467_2022_30269_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e8d/9090908/bedf66c80350/41467_2022_30269_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e8d/9090908/aaab79790947/41467_2022_30269_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e8d/9090908/68f1aa8ca596/41467_2022_30269_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e8d/9090908/9aa1dc8dec9e/41467_2022_30269_Fig4_HTML.jpg

相似文献

[1]
Systematic and quantitative view of the antiviral arsenal of prokaryotes.

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[2]
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[3]
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[7]
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[8]
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[9]
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[10]

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本文引用的文献

[1]
A unique mode of nucleic acid immunity performed by a multifunctional bacterial enzyme.

Cell Host Microbe. 2022-4-13

[2]
Phages and their satellites encode hotspots of antiviral systems.

Cell Host Microbe. 2022-5-11

[3]
A phage parasite deploys a nicking nuclease effector to inhibit viral host replication.

Nucleic Acids Res. 2022-8-26

[4]
Resolving the structure of phage-bacteria interactions in the context of natural diversity.

Nat Commun. 2022-1-18

[5]
Antiviral activity of bacterial TIR domains via immune signalling molecules.

Nature. 2021-12

[6]
Rapid evolutionary turnover of mobile genetic elements drives bacterial resistance to phages.

Science. 2021-10-22

[7]
Cyclic CMP and cyclic UMP mediate bacterial immunity against phages.

Cell. 2021-11-11

[8]
Identification and classification of antiviral defence systems in bacteria and archaea with PADLOC reveals new system types.

Nucleic Acids Res. 2021-11-8

[9]
Prophages encode phage-defense systems with cognate self-immunity.

Cell Host Microbe. 2021-11-10

[10]
Temporal shifts in antibiotic resistance elements govern phage-pathogen conflicts.

Science. 2021-7-30

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