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胸腺来源淋巴细胞在小鼠沙门氏菌病获得性免疫中的作用。

Role of thymus-derived lymphocytes in acquired immunity to salmonellosis in mice.

作者信息

Chander R, Sainis K B, Lewis N F

出版信息

Microbiol Immunol. 1986;30(12):1299-306. doi: 10.1111/j.1348-0421.1986.tb03062.x.

DOI:10.1111/j.1348-0421.1986.tb03062.x
PMID:3553871
Abstract

The relative role of thymus-derived (T-) lymphocytes and bone marrow-derived (B-) cells in acquired immunity to salmonellosis was examined in mice. The results demonstrate that the protective capacity of the donor immunized mice could be passively transferred to the recipient mice by spleen cells but not with peritoneal exudate cells or sera. A high cell number of spleen cells (2 X 10(8)/mouse) were required before passive transfer of immunity could be obtained. Of the T-lymphocytes and B-cell populations of spleen cells, T-cells from immune mice were effective in conferring protection to the recipient mice.

摘要

在小鼠中研究了胸腺来源的(T-)淋巴细胞和骨髓来源的(B-)细胞在沙门氏菌病获得性免疫中的相对作用。结果表明,供体免疫小鼠的保护能力可通过脾细胞被动转移给受体小鼠,但不能通过腹腔渗出细胞或血清转移。在获得免疫的被动转移之前,需要大量的脾细胞(2×10⁸/只小鼠)。在脾细胞的T淋巴细胞和B细胞群体中,来自免疫小鼠的T细胞能有效地赋予受体小鼠保护作用。

相似文献

1
Role of thymus-derived lymphocytes in acquired immunity to salmonellosis in mice.胸腺来源淋巴细胞在小鼠沙门氏菌病获得性免疫中的作用。
Microbiol Immunol. 1986;30(12):1299-306. doi: 10.1111/j.1348-0421.1986.tb03062.x.
2
Protective effects of passively transferred immune T- or B-lymphocytes in mice infected with Salmonella typhimurium.被动转移的免疫T淋巴细胞或B淋巴细胞对感染鼠伤寒沙门氏菌小鼠的保护作用。
J Infect Dis. 1977 May;135(5):813-23. doi: 10.1093/infdis/135.5.813.
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Mechanisms of acquired resistance in mouse typhoid.小鼠伤寒获得性耐药机制。
Microbiol Immunol. 1987;31(3):223-30. doi: 10.1111/j.1348-0421.1987.tb03086.x.
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Ribonucleic acid in the immune response.免疫反应中的核糖核酸
Mol Cell Biochem. 1978 Aug 16;20(3):131-47. doi: 10.1007/BF00243760.
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Intestinal Inflammation Leads to a Long-lasting Increase in Resistance to Systemic Salmonellosis that Requires Macrophages But Not B or T Lymphocytes at the Time of Pathogen Challenge.肠道炎症会导致对全身性沙门氏菌病的抵抗力长期增强,这种增强在病原体攻击时需要巨噬细胞,但不需要B淋巴细胞或T淋巴细胞。
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The effect of T and B lymphocyte depletion on the protection of mice vaccinated with a Gal E mutant of Salmonella typhimurium.T和B淋巴细胞耗竭对用鼠伤寒沙门氏菌Gal E突变株免疫的小鼠的保护作用。
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Experimental Salmonella typhimurium infections in rats. III. Transfer of immunity with primed lymphocyte subpopulations.大鼠实验性鼠伤寒沙门氏菌感染。III. 用致敏淋巴细胞亚群转移免疫力。
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Cellular aspects of the longer-lasting immunity against mouse typhoid infection afforded by the live-cell and ribosomal vaccines.活细胞疫苗和核糖体疫苗对小鼠伤寒感染产生的持久免疫的细胞方面。
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Membrane vesicles are immunogenic facsimiles of Salmonella typhimurium that potently activate dendritic cells, prime B and T cell responses, and stimulate protective immunity in vivo.膜泡是鼠伤寒沙门氏菌的免疫原性模拟物,可有效激活树突状细胞,启动B细胞和T细胞反应,并在体内刺激保护性免疫。
J Immunol. 2007 Dec 1;179(11):7692-701. doi: 10.4049/jimmunol.179.11.7692.

引用本文的文献

1
Adoptive transfer of immunity to oral challenge with virulent salmonellae in innately susceptible BALB/c mice requires both immune serum and T cells.将对致病性沙门氏菌口服攻击的免疫力过继转移给先天易感的BALB/c小鼠,既需要免疫血清也需要T细胞。
Infect Immun. 1993 Sep;61(9):3981-4. doi: 10.1128/iai.61.9.3981-3984.1993.
2
Modulation of resistance to Salmonella typhimurium infection in mice by mouse hepatitis virus (MHV).小鼠肝炎病毒(MHV)对小鼠抗鼠伤寒沙门氏菌感染抵抗力的调节作用。
Microb Pathog. 1989 Feb;6(2):81-91. doi: 10.1016/0882-4010(89)90011-9.
3
Predominant activation and expansion of V gamma 9-bearing gamma delta T cells in vivo as well as in vitro in Salmonella infection.
在沙门氏菌感染中,体内及体外均出现携带Vγ9的γδT细胞的主要激活和扩增。
J Clin Invest. 1992 Jul;90(1):204-10. doi: 10.1172/JCI115837.