Hochadel J F, Keller K F
J Infect Dis. 1977 May;135(5):813-23. doi: 10.1093/infdis/135.5.813.
Purified populations of bone marrow-derived (B-) lymphocytes and thymus-derived (T-) lymphocytes were obtained from C3D2F1 hybrid mice shown to be immune to Salmonella typhimurium. These subpopulations of lymphocytes were injected into normal mice; four days later the animals were challenged with 50 50% lethal doses of S. typhimurium, and viable bacteria in livers, spleens, and blood were counted at various intervals after challenge. On day 8 after challenge, the mice supplemented with B-lymphocytes showed a significant decrease in the number of organisms recovered from all three sites, compared with that seen in recipients of T-lymphocytes and in controls. The mice given B-lymphocytes showed a better rate of survival (65%) than mice that received only T-lymphocytes (21%) or T-lymphocyte fractions contaminated 10%-30% with B-lymphocytes (49%). These data indicate that, although the humoral response is not totally protective, it does play an important role in the suppression of the infection during its early stages.
从对鼠伤寒沙门氏菌具有免疫力的C3D2F1杂交小鼠中获得纯化的骨髓来源（B）淋巴细胞群和胸腺来源（T）淋巴细胞群。将这些淋巴细胞亚群注射到正常小鼠体内；四天后，用50个50%致死剂量的鼠伤寒沙门氏菌攻击这些动物，并在攻击后的不同时间间隔对肝脏、脾脏和血液中的活菌进行计数。在攻击后第8天，与接受T淋巴细胞的小鼠和对照组相比，补充B淋巴细胞的小鼠从所有三个部位回收的生物体数量显著减少。接受B淋巴细胞的小鼠存活率（65%）高于仅接受T淋巴细胞的小鼠（21%）或被10%-30%B淋巴细胞污染的T淋巴细胞组分的小鼠（49%）。这些数据表明，虽然体液反应并非完全具有保护作用，但它在感染早期的抑制中确实发挥着重要作用。
