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用于近红外二区成像和癌症诊疗的稀土掺杂纳米颗粒的最新进展

Recent Advances in Rare-Earth-Doped Nanoparticles for NIR-II Imaging and Cancer Theranostics.

作者信息

Yu Zhenfeng, Eich Christina, Cruz Luis J

机构信息

Translational Nanobiomaterials and Imaging Group, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands.

出版信息

Front Chem. 2020 Jun 17;8:496. doi: 10.3389/fchem.2020.00496. eCollection 2020.

DOI:10.3389/fchem.2020.00496
PMID:32656181
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7325968/
Abstract

Fluorescence imaging in the second near infrared window (NIR-II, 1,000-1,700 nm) has been widely used in cancer diagnosis and treatment due to its high spatial resolution and deep tissue penetration depths. In this work, recent advances in rare-earth-doped nanoparticles (RENPs)-a novel kind of NIR-II nanoprobes-are presented. The main focus of this study is on the modification of RENPs and their applications in NIR-II and imaging and cancer theranostics. Finally, the perspectives and challenges of NIR-II RENPs are discussed.

摘要

第二近红外窗口（NIR-II，1000 - 1700纳米）的荧光成像因其高空间分辨率和深组织穿透深度而被广泛应用于癌症诊断和治疗。在这项工作中，介绍了稀土掺杂纳米粒子（RENPs）——一种新型的NIR-II纳米探针——的最新进展。本研究的主要重点是RENPs的修饰及其在NIR-II成像和癌症诊疗中的应用。最后，讨论了NIR-II RENPs的前景和挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f713/7325968/e9896369f301/fchem-08-00496-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f713/7325968/07cca5072982/fchem-08-00496-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f713/7325968/7efcc41735a6/fchem-08-00496-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f713/7325968/434c2e421694/fchem-08-00496-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f713/7325968/e9896369f301/fchem-08-00496-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f713/7325968/07cca5072982/fchem-08-00496-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f713/7325968/7efcc41735a6/fchem-08-00496-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f713/7325968/434c2e421694/fchem-08-00496-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f713/7325968/e9896369f301/fchem-08-00496-g0004.jpg

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2
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J Mater Chem B. 2017 Mar 14;5(10):1917-1925. doi: 10.1039/c7tb00070g. Epub 2017 Feb 9.
3
Nd-doped LiYF nanocrystals for bio-imaging in the second near-infrared window.
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Polymers (Basel). 2023 Sep 21;15(18):3853. doi: 10.3390/polym15183853.
4
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5
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6
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