El Rhaoussi Fatima Zahra, Banani Soukaina, Bouamama Sophia, Bennani Nissrine, Badre Wafaa
Gastroenterology and Hepatology, Ibn Rochd University Hospital Center, Hassan II University of Casablanca, Faculty of Medicine and Pharmacy, Casablanca, MAR.
Anatomical Pathology, Ibn Rochd University Hospital Center, Hassan II University of Casablanca, Faculty of Medicine and Pharmacy, Casablanca, MAR.
Cureus. 2022 Apr 8;14(4):e23967. doi: 10.7759/cureus.23967. eCollection 2022 Apr.
Sarcoidosis is a systemic granulomatous disease of unknown etiology, characterized by the presence of non-caseating granulomas. Gastrointestinal involvement in sarcoidosis is extremely rare. However, hepatic sarcoidosis occurs in 70% of cases. This is a case report of multisystemic sarcoidosis revealed by hepatosplenomegaly. The patient presented initially with asthenia, anorexia, and weight loss. An abdominal computed tomography scan revealed hepatosplenomegaly and lumbo-aortic adenopathy. During hospitalization, the patient presented an extended erythematous cutaneous lesion in the peri-auricular area. The diagnosis of sarcoidosis was confirmed by salivary, cutaneous, and bronchoscopic biopsy, which revealed the presence of epithelioid granuloma without necrosis. Consequently, the patient was treated with oral corticosteroids with good improvement.
结节病是一种病因不明的全身性肉芽肿性疾病,其特征是存在非干酪样肉芽肿。结节病累及胃肠道极为罕见。然而,70%的病例会出现肝结节病。这是一例因肝脾肿大而发现的多系统结节病的病例报告。患者最初表现为乏力、厌食和体重减轻。腹部计算机断层扫描显示肝脾肿大和腰主动脉淋巴结肿大。住院期间,患者耳周区域出现了一处扩大的红斑性皮肤损害。通过唾液、皮肤和支气管镜活检确诊为结节病,活检显示存在无坏死的上皮样肉芽肿。因此,患者接受了口服糖皮质激素治疗,病情有明显改善。