一种具有HO特异性响应和AIE活性的单分子诊疗系统，用于阿霉素在活细胞中的释放和实时追踪。

A unimolecular theranostic system with HO-specific response and AIE-activity for doxorubicin releasing and real-time tracking in living cells.

作者信息

Gao Xiaoying, Cao Jie, Song Yinuo, Shu Xiao, Liu Jianzhao, Sun Jing Zhi, Liu Bin, Tang Ben Zhong

机构信息

MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University Hangzhou 310027 China

Department of Chemical and Biomolecular Engineering, National University of Singapore 4 Engineering Drive 4 Singapore 117585 Singapore

出版信息

RSC Adv. 2018 Mar 20;8(20):10975-10979. doi: 10.1039/c8ra01185k. eCollection 2018 Mar 16.

A theranostic drug delivery system composed of tetraphenyl-ethene (AIEgen), benzyl boronic ester (trigger), and doxorubicin (drug) was designed and synthesized; its utilities for cell imaging, drug delivery tracking, and cancer cell cytociding were evaluated.