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一种具有HO特异性响应和AIE活性的单分子诊疗系统，用于阿霉素在活细胞中的释放和实时追踪。

A unimolecular theranostic system with HO-specific response and AIE-activity for doxorubicin releasing and real-time tracking in living cells.

作者信息

Gao Xiaoying, Cao Jie, Song Yinuo, Shu Xiao, Liu Jianzhao, Sun Jing Zhi, Liu Bin, Tang Ben Zhong

机构信息

MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University Hangzhou 310027 China

Department of Chemical and Biomolecular Engineering, National University of Singapore 4 Engineering Drive 4 Singapore 117585 Singapore

出版信息

RSC Adv. 2018 Mar 20;8(20):10975-10979. doi: 10.1039/c8ra01185k. eCollection 2018 Mar 16.

DOI:10.1039/c8ra01185k
PMID:35541547
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9078942/
Abstract

A theranostic drug delivery system composed of tetraphenyl-ethene (AIEgen), benzyl boronic ester (trigger), and doxorubicin (drug) was designed and synthesized; its utilities for cell imaging, drug delivery tracking, and cancer cell cytociding were evaluated.

摘要

设计并合成了一种由四苯基乙烯（聚集诱导发光剂）、苄基硼酸酯（触发剂）和阿霉素（药物）组成的诊疗药物递送系统；评估了其在细胞成像、药物递送追踪和癌细胞杀伤方面的效用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16e1/9078942/62226ddc1189/c8ra01185k-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16e1/9078942/f56859ee27bb/c8ra01185k-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16e1/9078942/c75b80973250/c8ra01185k-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16e1/9078942/a815acfb49b8/c8ra01185k-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16e1/9078942/9c9ede9ee25b/c8ra01185k-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16e1/9078942/62226ddc1189/c8ra01185k-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16e1/9078942/f56859ee27bb/c8ra01185k-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16e1/9078942/c75b80973250/c8ra01185k-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16e1/9078942/a815acfb49b8/c8ra01185k-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16e1/9078942/9c9ede9ee25b/c8ra01185k-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16e1/9078942/62226ddc1189/c8ra01185k-f4.jpg

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