Graduate School of Science and ‡Molecular Chirality Research Center, Chiba University , Yayoi-cho 1-33, Inage-ku, Chiba 263-8522, Japan.
J Org Chem. 2017 Jan 6;82(1):170-178. doi: 10.1021/acs.joc.6b02303. Epub 2016 Dec 15.
Treatment of quinolines and isoquinolines with benzoyl peroxide in tertiary amides, such as N,N-dimethylacetamide, N,N-dimethylpropionamide, and N-acetylpyrrolidine, etc., under irradiation with a Hg lamp in the temperature range of 35 °C to 40 °C gave C-C-bonded quinolines and isoquinolines bearing amide groups with high regioselectivity in good to moderate yields, respectively, under transition-metal-free conditions.
在 35°C 至 40°C 的温度范围内，用汞灯照射，在三酰胺（如 N，N-二甲基乙酰胺、N，N-二甲基丙酰胺和 N-乙酰基吡咯烷等）中用过氧化苯甲酰处理喹啉和异喹啉，可以在无过渡金属条件下，以良好至中等收率、高度区域选择性地得到 C-C 键合的带有酰胺基团的喹啉和异喹啉。
