Feng Huayang, Chu Dandan, Li Zhanrong, Guo Zhihua, Jin Lin, Fan Bingbing, Zhang Junjie, Li Jingguo
People's Hospital of Zhengzhou University, Zhengzhou University Henan 450003 China
School of Material Science and Engineering, Zhengzhou University Henan 450001 China
RSC Adv. 2018 Jul 19;8(46):25949-25954. doi: 10.1039/c8ra04089c.
A novel triblock polymer is synthesized and self-assembled with doxorubicin to form DOX-loaded micelles. The synthetic process involves the ring-opening polymerization, carboxylation and amidation reactions, and the structures are characterized. The drug release test indicated that the micelles have the ability to control the release of drugs. The cell uptake results indicated that the DOX-loaded micelles could enter cancer cells easily, and the cytotoxicity and apoptosis test confirmed that DOX-loaded micelles have a strong killing effect on tumor cells, while the blank micelles do not have cytotoxicity. Therefore, the novel polymer micelles are a promising carrier for delivery of anticancer drugs to enhance cancer treatment.
合成了一种新型三嵌段聚合物，并将其与阿霉素自组装形成载阿霉素胶束。合成过程涉及开环聚合、羧化和酰胺化反应，并对结构进行了表征。药物释放试验表明，该胶束具有控制药物释放的能力。细胞摄取结果表明，载阿霉素胶束能够轻松进入癌细胞，细胞毒性和凋亡试验证实，载阿霉素胶束对肿瘤细胞具有很强的杀伤作用，而空白胶束没有细胞毒性。因此，这种新型聚合物胶束是一种很有前途的抗癌药物递送载体，可增强癌症治疗效果。
