Yang Qiang, Zhang Ai-Hua, Miao Jian-Hua, Sun Hui, Han Ying, Yan Guang-Li, Wu Fang-Fang, Wang Xi-Jun
Department of Pharmaceutical Analysis, National Engineering Laboratory for the Development of Southwestern Endangered Medicinal Materials, Guangxi Botanical Garden of Medicinal Plant, National Chinmedomics Research Center, Sino-America Chinmedomics Technology Collaboration Center, National TCM Key Laboratory of Serum Pharmacochemistry, Laboratory of Metabolomics, Heilongjiang University of Chinese Medicine Heping Road 24 Harbin China
RSC Adv. 2019 Nov 14;9(64):37245-37257. doi: 10.1039/c9ra06697g. eCollection 2019 Nov 13.
Given the highly increased incidence of human diseases, a better understanding of the related mechanisms regarding endogenous metabolism is urgently needed. Mass spectrometry-based metabolomics has been used in a variety of disease research areas. However, the deep research of metabolites remains a difficult and lengthy process. Fortunately, mass spectrometry is considered to be a universal tool with high specificity and sensitivity and is widely used around the world. Mass spectrometry technology has been applied to various basic disciplines, providing technical support for the discovery and identification of endogenous substances in living organisms. The combination of metabolomics and mass spectrometry is of great significance for the discovery and identification of metabolite biomarkers. The mass spectrometry tool could further improve and develop the exploratory research of the life sciences. This mini review discusses metabolomics biotechnology with a focus on recent applications of metabolomics as a powerful tool to elucidate metabolic disturbances and the related mechanisms of diseases.
鉴于人类疾病的发病率急剧上升，迫切需要更好地了解内源性代谢的相关机制。基于质谱的代谢组学已应用于各种疾病研究领域。然而，对代谢物的深入研究仍然是一个困难且漫长的过程。幸运的是，质谱被认为是一种具有高特异性和灵敏度的通用工具，在全球范围内广泛使用。质谱技术已应用于各种基础学科，为发现和鉴定生物体内的内源性物质提供技术支持。代谢组学与质谱的结合对于发现和鉴定代谢物生物标志物具有重要意义。质谱工具可以进一步改进和发展生命科学的探索性研究。本综述讨论了代谢组学生物技术，重点关注代谢组学作为阐明代谢紊乱和疾病相关机制的强大工具的最新应用。
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