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哈茨木霉A和B：两种源自珊瑚的真菌中的羟基蒽醌

Harzianumnones A and B: two hydroxyanthraquinones from the coral-derived fungus .

作者信息

Shi Ting, Hou Xue-Mei, Li Zhi-Yong, Cao Fei, Zhang Ya-Hui, Yu Jia-Yin, Zhao Dong-Lin, Shao Chang-Lun, Wang Chang-Yun

机构信息

Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China Qingdao 266003 People's Republic of China

Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology Qingdao 266071 People's Republic of China.

出版信息

RSC Adv. 2018 Aug 2;8(49):27596-27601. doi: 10.1039/c8ra04865g.

DOI:10.1039/c8ra04865g
PMID:35542739
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9083448/
Abstract

Two new hydroxyanthraquinones, harzianumnones A (1) and B (2), together with seven known analogs (3-9), were isolated from the soft coral-derived fungus (XS-20090075). Their chemical structures were elucidated by extensive spectroscopic investigation. The absolute configurations of 1 and 2 were determined by ECD calculation and single-crystal X-ray diffraction. Compounds 1 and 2 were identified as a pair of epimers, which are the first example of hydroanthraquinones from . Compounds 7 and 8 exhibited cytotoxicity against hepatoma cell line HepG2 with IC values of 2.10 and 9.39 μM, respectively. Compound 7 was still found to show cytotoxicity against cervical cancer cell line HeLa with an IC value of 8.59 μM.

摘要

从软珊瑚来源的真菌（XS - 20090075）中分离出两种新的羟基蒽醌，哈茨木醌A（1）和B（2），以及七种已知类似物（3 - 9）。通过广泛的光谱研究阐明了它们的化学结构。通过电子圆二色光谱（ECD）计算和单晶X射线衍射确定了1和2的绝对构型。化合物1和2被鉴定为一对差向异构体，这是来自该真菌的氢蒽醌的首个实例。化合物7和8对肝癌细胞系HepG2表现出细胞毒性，IC值分别为2.10和9.39 μM。还发现化合物7对宫颈癌细胞系HeLa表现出细胞毒性，IC值为8.59 μM。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d77/9083448/fe6a7a343275/c8ra04865g-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d77/9083448/c5067f27b734/c8ra04865g-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d77/9083448/8a2b059528e5/c8ra04865g-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d77/9083448/14eca4c6311d/c8ra04865g-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d77/9083448/c30e0a859618/c8ra04865g-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d77/9083448/3ad8ae1c2886/c8ra04865g-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d77/9083448/c771d122eba3/c8ra04865g-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d77/9083448/fe6a7a343275/c8ra04865g-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d77/9083448/c5067f27b734/c8ra04865g-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d77/9083448/8a2b059528e5/c8ra04865g-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d77/9083448/14eca4c6311d/c8ra04865g-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d77/9083448/c30e0a859618/c8ra04865g-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d77/9083448/3ad8ae1c2886/c8ra04865g-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d77/9083448/c771d122eba3/c8ra04865g-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d77/9083448/fe6a7a343275/c8ra04865g-f7.jpg

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