哈茨木霉A和B：两种源自珊瑚的真菌中的羟基蒽醌

Harzianumnones A and B: two hydroxyanthraquinones from the coral-derived fungus .

作者信息

Shi Ting, Hou Xue-Mei, Li Zhi-Yong, Cao Fei, Zhang Ya-Hui, Yu Jia-Yin, Zhao Dong-Lin, Shao Chang-Lun, Wang Chang-Yun

机构信息

Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China Qingdao 266003 People's Republic of China

Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology Qingdao 266071 People's Republic of China.

出版信息

RSC Adv. 2018 Aug 2;8(49):27596-27601. doi: 10.1039/c8ra04865g.

Two new hydroxyanthraquinones, harzianumnones A (1) and B (2), together with seven known analogs (3-9), were isolated from the soft coral-derived fungus (XS-20090075). Their chemical structures were elucidated by extensive spectroscopic investigation. The absolute configurations of 1 and 2 were determined by ECD calculation and single-crystal X-ray diffraction. Compounds 1 and 2 were identified as a pair of epimers, which are the first example of hydroanthraquinones from . Compounds 7 and 8 exhibited cytotoxicity against hepatoma cell line HepG2 with IC values of 2.10 and 9.39 μM, respectively. Compound 7 was still found to show cytotoxicity against cervical cancer cell line HeLa with an IC value of 8.59 μM.