Dubois A, Dorval E D, Steel L, Fiala N P, Conklin J J
Radiat Res. 1987 May;110(2):289-93.
Early radiation toxicity is characterized by nausea and vomiting. We have previously shown that gastric emptying, gastric motility, and gastric secretion were suppressed after total body exposure to irradiation. In the present studies, we evaluated the relation between vomiting and gastric function in nine rhesus monkeys and explored the possible role of prostaglandins (PG) in these phenomena. The concentration of PG in plasma and gastric juice was determined using a standard radioimmunoassay and gastric acid output was measured concurrently using a marker dilution technique. The animals were studied in the basal state and after total body exposure to 800 cGy 60Co delivered at a rate of 500 cGy/min. Acid output was abolished from 40 min to 2 h after irradiation but had returned to preirradiation levels 2 days later. Plasma PGE2 and PGI2 (as measured by 6-keto-PGF1 alpha determination) were not significantly modified by irradiation. In contrast, irradiation produced an immediate significant increase (P less than 0.05) in gastric juice concentration of PGE2 (318 +/- 80 to 523 +/- 94 pg/ml; mean +/- SE) and PGI2 (230 +/- 36 to 346 +/- 57 pg/ml); both had returned to basal levels 2 days later. Thus, an increase in gastric juice concentration of both PGE2 and PGI2 is associated with the radiation induced suppression of acid output.
早期辐射毒性的特征为恶心和呕吐。我们之前已经表明，全身照射后胃排空、胃动力和胃分泌受到抑制。在本研究中，我们评估了9只恒河猴呕吐与胃功能之间的关系，并探讨了前列腺素（PG）在这些现象中可能发挥的作用。使用标准放射免疫分析法测定血浆和胃液中PG的浓度，并同时使用标记稀释技术测量胃酸分泌量。在基础状态下以及全身接受以500 cGy/分钟的剂量率给予的800 cGy 60Co照射后对动物进行研究。照射后40分钟至2小时胃酸分泌量消失，但2天后恢复到照射前水平。照射对血浆PGE2和PGI2（通过测定6-酮-PGF1α来测量）没有显著影响。相比之下，照射使胃液中PGE2（从318±80至523±94 pg/ml；平均值±标准误）和PGI2（从230±36至346±57 pg/ml）的浓度立即显著增加（P<0.05）；两者在2天后均恢复到基础水平。因此，胃液中PGE2和PGI2浓度的增加与辐射诱导的胃酸分泌抑制有关。
