活性纳米马达超越被动纳米药物：当前进展与挑战

Active nanomotors surpass passive nanomedicines: current progress and challenges.

作者信息

Chen Shuqin, Chen Yuduo, Fu Mingming, Cao Qinghua, Wang Bo, Chen Wenjun, Ma Xing

机构信息

School of Materials Science and Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen, 518055, China.

Sauvage Laboratory for Smart Materials, School of Materials Science and Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen, 518055, China.

出版信息

J Mater Chem B. 2022 Sep 28;10(37):7099-7107. doi: 10.1039/d2tb00556e.

DOI:10.1039/d2tb00556e

PMID:35543361

Abstract

Artificial nanomotors show advantages over traditional nanomedicines in biomedical applications due to their active locomotion by converting various energy sources into mechanical force . Currently, nanomotors are attracting wide attention in diagnosis and therapy towards clinical applications. In this perspective, we summarize recent developments of nanomotors in biomedical applications, including targeted drug delivery, biological barrier penetration, and diagnostics and cancer treatment. The development of nanomotors in biomedicine still faces considerable challenges and practical difficulties towards clinical use, which are discussed in detail. Finally, we propose potential solutions that may help the development of nanomotors towards advanced diagnostics and therapy.

摘要

人工纳米马达在生物医学应用中比传统纳米药物具有优势，因为它们通过将各种能源转化为机械力来实现主动运动。目前，纳米马达在临床应用的诊断和治疗方面正引起广泛关注。从这个角度出发，我们总结了纳米马达在生物医学应用中的最新进展，包括靶向药物递送、生物屏障穿透以及诊断和癌症治疗。纳米马达在生物医学中的发展在临床应用方面仍面临相当大的挑战和实际困难，本文将对此进行详细讨论。最后，我们提出了一些潜在的解决方案，可能有助于纳米马达向先进的诊断和治疗方向发展。