Department of Emergency Medicine, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.
Eur J Pharmacol. 2022 Jul 5;926:175011. doi: 10.1016/j.ejphar.2022.175011. Epub 2022 May 11.
Cancer overlooks are globally one of the most dangerous and life-threatening tribulations. While significant advances have been made in the targeted delivery of anti-cancer medications over the last few years, several challenges, such as low efficacy and strong toxic effects, remain to be addressed. Micro/nanomotors have been thoroughly studied for both effective cancer detection and treatment, as demonstrated by significant advancements in the architecture of smart and functional micro/nanomotor biomedical systems. Able to self-propelled within fluid media, micro/nanomotors have attractive vehicles to maximize the efficacy of tumor delivery. Here, we present the current developments in the delivery, detection, and imaging-guided treatment of micro/nanomotors in the clinical field, including cancer-related specific targeted drug delivery, and then discuss the barriers and difficulties encountered by micro/nanomotors throughout the medical process. Furthermore, this paper addresses the potential growth of micro/nanomotors for medical applications, and sets out the current drawbacks and future research directions for more advancement.
癌症忽视是全球最危险和最具威胁生命的磨难之一。尽管在过去几年中，在抗癌药物的靶向递送方面取得了重大进展，但仍存在一些挑战，如疗效低和毒性强。微/纳米马达已被彻底研究用于有效癌症检测和治疗，这体现在智能和功能微/纳米马达生物医学系统的架构方面取得了重大进展。微/纳米马达能够在流体介质中自主推进，是具有吸引力的载体，可以最大限度地提高肿瘤输送的效果。在这里，我们介绍了微/纳米马达在临床领域中的输送、检测和成像引导治疗方面的最新进展，包括与癌症相关的特定靶向药物输送，然后讨论了微/纳米马达在整个医疗过程中遇到的障碍和困难。此外，本文还探讨了微/纳米马达在医学应用中的潜在发展，并提出了当前的缺点和未来的研究方向，以推动进一步发展。
