Adelaide Exposure Science and Health, School of Public Health, University of Adelaide, Adelaide, South Australia, Australia.
Department of Defence, Irregular Warfare Technical Support Directorate, Technical Support Working Group, US Government, Alexandria, Virginia, USA.
J Occup Environ Hyg. 2022 Jul;19(7):411-414. doi: 10.1080/15459624.2022.2076862. Epub 2022 Jun 3.
This paper presents experimental data on the skin absorption of sodium fluoroacetate from a formulated product using an approach and human skin. Sodium fluoroacetate is a pesticide, typically applied in formulation (1080) for the control of unwanted vertebrate invasive species. It has been assigned a Skin Notation by the ACGIH, and other international workplace health regulatory bodies, due to its predicted ability to permeate intact and abraded human skin. However, there is a distinct lack of experimental data on the skin absorption of sodium fluoroacetate to support this assignment. This study found that sodium fluoroacetate, as a formulated product, permeated the human epidermis when in direct contact for greater than 10 hr. A steady-state flux (J) of 1.31 ± 0.043 µg/cm/hr and a lag time of 6.1 hr was calculated from cumulative skin permeation data. This study provides important empirical evidence in support of the assignment of a Skin Notation.
本文提供了使用 方法和人体皮肤从配方产品中测定氟乙酸钠经皮吸收的实验数据。氟乙酸钠是一种杀虫剂，通常以配方（1080）的形式用于控制不需要的脊椎动物入侵物种。由于其预测能够穿透完整和擦伤的人体皮肤，ACGIH 和其他国际工作场所健康监管机构已将其指定为皮肤标识物。然而，几乎没有关于氟乙酸钠经皮吸收的实验数据来支持这一指定。本研究发现，当氟乙酸钠配方产品与人表皮直接接触超过 10 小时时，会渗透进入人体表皮。从累积皮肤渗透数据中计算出稳态通量（J）为 1.31±0.043µg/cm/hr，滞后时间为 6.1 小时。本研究提供了重要的经验证据，支持了皮肤标识物的指定。
