Heart Failure with preserved Ejection Fraction (HFpEF) is a heterogeneous disease, which is becoming a worldwide menace. By retrieving the relevant literature of HFpEF from 2000 to 2021, qualitative and quantitative evaluations are carried out to visualize the scientific achievements in this field. The data were from the Web of Science Core Collection database. The bibliometric tool-CiteSpace is used for scientific econometric analysis to understand the development of disciplines and research hotspots in this field. A total of 6318 HFpEF-related research papers were collected by Web of Science Core Collection database from 2000 to 2021, and the number of published papers and citations were in the rising stage. Fund-funded publications accounted for 80.4 percent of total publications, mainly at the national level, with the largest number being funded by the United States Department of Health and Public Services. The number of publications and centrality of the USA ranked first, indicating that the USA is mature in this research field and is in a leading position in the industry, which may benefit from the contributions of scientific research institutions such as Mayo Medical Center, Brigham Women's Hospital, Northwest University and Duke University. Low-income and middle-income countries lag far behind developed countries in terms of health care and scientific research and need to strengthen international cooperation. Bibliometric analysis shows that the main research directions of HFpEF are epidemiology, treatment, and comorbidity research of HFpEF and atrial fibrillation. Chronic microvascular inflammation is the latest research paradigm of HFpEF, especially phosphodiesterase 5 inhibitors.