Li Zhenhao, Pei Baocheng, Ma Jun, Zhu Yuxiang, Sun Zhongdong
Department of Cardiac Surgery, Weifang People's Hospital, Shandong Second Medical University, 151 Guangwen Street, Kuiwen District, Weifang, Shandong, 261000, China.
J Cardiothorac Surg. 2025 Aug 5;20(1):322. doi: 10.1186/s13019-025-03563-y.
Restoration of blood flow after tissue ischemia aggravates the injury, a phenomenon known as ischemia-reperfusion injury. And ischemia-reperfusion injury of myocardium becomes a common cause of death after surgery in many patients. Relevant studies have proved that ischemia-reperfusion of myocardium has a strong correlation with autophagy, macrophage, endoplasmic reticulum, etc. Therefore, this paper systematically summarises and discusses the macrophage research in myocardial ischemia-reperfusion injury through visual research and metrological analysis, hoping to point out the direction for the researcher in this field.
We conducted a comprehensive search of publications on myocardial IRI and macrophages in the Web of Science Core Collection (WoSCC) database, covering the period from 2008 to June 2024. Bibliometric tools (CiteSpace, VOSviewer, and Excel) were used to analyze various factors such as publication trends, countries, institutions, journals, authors, and keywords. Visual maps were created to identify current research hotspots and forecast future developments in the field.
For this study we included a total of 1039 relevant studies, with a dynamic upward trend in the number of publications. China and the United States are in the top two in terms of the number of publications. The institution with the most publications is Fudan University, and the one with the most collaborations is the Chinese Academy of Medical Sciences. We also obtained the most publications with the highest number of citations and the highest impact factor. Inflammatory processes, mitochondrial autophagy, endoplasmic reticulum stress, and macrophages are current hotspots. Exploring molecular proteins and effective strategies to inhibit myocardial I/R injury may become the focus of future research.
Macrophages have emerged as a key area of focus in myocardial IRI research in recent years. This is the first bibliometric study to comprehensively analyze the research landscape on macrophages and myocardial IRI, providing valuable insights for researchers and guiding future developments in the field.
组织缺血后恢复血流会加重损伤，这种现象称为缺血再灌注损伤。心肌缺血再灌注损伤是许多患者术后常见的死亡原因。相关研究证明，心肌缺血再灌注与自噬、巨噬细胞、内质网等密切相关。因此，本文通过可视化研究和计量分析，系统总结并探讨了巨噬细胞在心肌缺血再灌注损伤中的研究，希望为该领域的研究人员指明方向。
我们在科学网核心合集（WoSCC）数据库中全面检索了关于心肌缺血再灌注损伤（IRI）和巨噬细胞的出版物，涵盖2008年至2024年6月期间。使用文献计量工具（CiteSpace、VOSviewer和Excel）分析出版趋势、国家、机构、期刊、作者和关键词等各种因素。创建可视化地图以识别当前研究热点并预测该领域的未来发展。
本研究共纳入1039项相关研究，出版物数量呈动态上升趋势。中国和美国在出版物数量方面位居前两位。发表论文最多的机构是复旦大学，合作最多的是中国医学科学院。我们还获得了被引次数最多和影响因子最高的出版物。炎症过程、线粒体自噬、内质网应激和巨噬细胞是当前的热点。探索抑制心肌I/R损伤的分子蛋白和有效策略可能成为未来研究的重点。
近年来，巨噬细胞已成为心肌IRI研究的关键重点领域。这是第一项全面分析巨噬细胞与心肌IRI研究格局的文献计量学研究，为研究人员提供了有价值的见解，并指导该领域的未来发展。
