Basic Medical College, Harbin Medical University, Harbin, People's Republic of China.
School of Nursing, Southern Medical University, Guangzhou, People's Republic of China.
Int J Nanomedicine. 2024 Jul 29;19:7631-7671. doi: 10.2147/IJN.S461514. eCollection 2024.
Psoriasis is an immune-mediated inflammatory skin disease where topical therapy is crucial. While various dosage forms have enhanced the efficacy of current treatments, their limited permeability and lack of targeted delivery to the dermis and epidermis remain challenges. We reviewed the evolution of topical therapies for psoriasis and conducted a bibliometric analysis from 1993 to 2023 using a predictive linear regression model. This included a comprehensive statistical and visual evaluation of each model's validity, literature profiles, citation patterns, and collaborations, assessing R variance and mean squared error (MSE). Furthermore, we detailed the structural features and penetration pathways of emerging drug delivery systems for topical treatment, such as lipid-based, polymer-based, metallic nanocarriers, and nanocrystals, highlighting their advantages. This systematic overview indicates that future research should focus on developing novel drug delivery systems characterized by enhanced stability, biocompatibility, and drug-carrying capacity.
银屑病是一种免疫介导的炎症性皮肤疾病，局部治疗至关重要。虽然各种剂型提高了现有治疗方法的疗效，但它们向真皮和表皮的通透性有限且缺乏靶向性仍然是挑战。我们回顾了银屑病的局部治疗进展，并使用预测线性回归模型对 1993 年至 2023 年的文献进行了文献计量学分析。该模型对每个模型的有效性、文献概况、引文模式和合作关系进行了全面的统计和可视化评估，评估了 R 方差和均方误差 (MSE)。此外，我们详细介绍了新兴局部治疗药物传递系统的结构特征和渗透途径，例如基于脂质、基于聚合物、金属纳米载体和纳米晶体，突出了它们的优势。该系统综述表明，未来的研究应侧重于开发具有增强的稳定性、生物相容性和载药能力的新型药物传递系统。
