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孤立性第六神经麻痹:多发性硬化症的罕见首发表现。

Isolated sixth nerve palsy: a rare first presentation in multiple sclerosis.

机构信息

Ophthalmology, NHS Lothian, Edinburgh, UK

Ophthalmology, NHS Tayside, Dundee, UK.

出版信息

BMJ Case Rep. 2022 May 11;15(5):e247928. doi: 10.1136/bcr-2021-247928.

DOI:10.1136/bcr-2021-247928
PMID:35545312
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9096498/
Abstract

True isolated sixth nerve palsy as the initial presentation of multiple sclerosis (MS) is rare. MS is a chronic inflammatory, immune-mediated disease of the central nervous system. This is the most common cause of neurological disability in young adults. Common symptoms include acute episodes of muscle weakness, altered sensation, balance and gait disturbances, visual loss and bladder dysfunction.Diagnosis of MS is supported with the incidence of symptomatic clinical episodes with subsequent cross-sectional imaging to confirm radiological lesions that are disseminated in space and time.In the following report, we discuss the case of a woman in her 30s who presented to ophthalmology with a sixth nerve palsy in the absence of ocular or systemic disease. This is the first presentation of MS, a rare clinical event.

摘要

真正孤立性第六脑神经麻痹作为多发性硬化症(MS)的初始表现较为罕见。MS 是一种中枢神经系统的慢性炎症性、免疫介导性疾病。这是年轻人中最常见的神经功能障碍原因。常见症状包括急性肌肉无力发作、感觉改变、平衡和步态障碍、视力丧失和膀胱功能障碍。MS 的诊断依据是有症状的临床发作的发生率,随后进行横断面成像以确认在空间和时间上弥散的放射学病变。在下面的报告中,我们讨论了一位 30 多岁的女性患者,她因第六脑神经麻痹就诊于眼科,而眼部或全身均无疾病。这是 MS 的首次表现,是一种罕见的临床事件。

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本文引用的文献

1
Isolated Sixth Nerve Palsy as a First Presentation of Nasopharyngeal Carcinoma: A Case Series.孤立性第六脑神经麻痹作为鼻咽癌的首发表现:病例系列
Int Med Case Rep J. 2021 Nov 23;14:801-808. doi: 10.2147/IMCRJ.S334476. eCollection 2021.
2
Abducens nerve palsy with associated retinal involvement secondary to rickettsia typhi infection.鼠伤寒立克次体感染继发外展神经麻痹伴视网膜受累
J Ophthalmic Inflamm Infect. 2021 Mar 22;11(1):9. doi: 10.1186/s12348-021-00239-1.
3
Epidemiology, characteristics and treatment of patients with relapsing remitting multiple sclerosis and incidence of high disease activity: Real world evidence based on German claims data.复发缓解型多发性硬化症患者的流行病学、特征和治疗以及高疾病活动度的发生率:基于德国索赔数据的真实世界证据。
PLoS One. 2020 May 1;15(5):e0231846. doi: 10.1371/journal.pone.0231846. eCollection 2020.
4
Differential diagnosis of multiple sclerosis and other inflammatory CNS diseases.多发性硬化症和其他中枢神经系统炎症性疾病的鉴别诊断。
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Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria.多发性硬化症的诊断:2017 年麦当劳标准修订版。
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Isolated Abducens Palsy as the First Presenting Sign of Multiple Sclerosis.孤立性外展神经麻痹作为多发性硬化症的首发症状
Case Rep Neurol. 2017 Jan 3;8(3):272-275. doi: 10.1159/000455023. eCollection 2016 Sep-Dec.
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Isolated Abducens Nerve Palsy: Update on Evaluation and Diagnosis.孤立性展神经麻痹:评估与诊断的最新进展
Curr Neurol Neurosci Rep. 2016 Aug;16(8):69. doi: 10.1007/s11910-016-0671-4.
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Revised Recommendations of the Consortium of MS Centers Task Force for a Standardized MRI Protocol and Clinical Guidelines for the Diagnosis and Follow-Up of Multiple Sclerosis.多发性硬化症中心联盟特别工作组关于标准化MRI方案及多发性硬化症诊断与随访临床指南的修订建议。
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9
Evidence-based guidelines: MAGNIMS consensus guidelines on the use of MRI in multiple sclerosis--establishing disease prognosis and monitoring patients.循证指南:磁共振成像在多发性硬化中的应用——建立疾病预后和监测患者的 MAGNIMS 共识指南。
Nat Rev Neurol. 2015 Oct;11(10):597-606. doi: 10.1038/nrneurol.2015.157. Epub 2015 Sep 15.
10
The diagnostic yield of neuroimaging in sixth nerve palsy--Sankara Nethralaya Abducens Palsy Study (SNAPS): Report 1.第六神经麻痹中神经影像学的诊断价值——桑卡拉奈特拉亚外展神经麻痹研究(SNAPS):报告1
Indian J Ophthalmol. 2014 Oct;62(10):1008-12. doi: 10.4103/0301-4738.146000.