Department of Radiology, Shengli Oilfield Central Hospital, Dongying, 257034, China.
CT Room, Dongying People's Hospital, 317 Dongchengnanyi Road, Dongying, 257091, China.
World J Surg Oncol. 2022 May 11;20(1):152. doi: 10.1186/s12957-022-02616-z.
To evaluate the diagnostic accuracy of single gastroscopy, multi-slice spiral CT, HER-2 or tumor markers, and their combination in the diagnosis of gastric cancer.
A total of 98 patients with gastric cancer were selected as the research subjects. All patients underwent preoperative gastroscopy, MSCT, and the expression levels of HER-2, CEA, CA199, CA724, and CA242 were detected. A control group of 98 normal adults was selected to compare the risk factors for gastric cancer and to analyze the data.
There was statistical significance in the expression of the 5 markers in tumor size (P < 0.05), but no statistical significance in other clinical data (P > 0.05). The tumor marker CEA in gastric mucosal tissue of patients with gastric cancer had the highest positive detection rate for gastric cancer, and the difference was statistically significant (P < 0.05) compared with gastroscopy, MSCT and other markers. The combined diagnosis had higher sensitivity, specificity and accuracy compared with the single diagnosis of gastric cancer staging, and the difference was statistically significant (P < 0.05). Compared with normal adults, patients with gastric cancer had statistically significant differences in diet, body mass index, and family genetic history (P < 0.05), while there was no statistically significant difference in whether they had type A blood (P > 0.05).
The combined diagnosis of gastroscopy, MSCT, immunohistochemical marker Her-2, and tumor markers CEA, CA199, CA724, and CA242 can more accurately determine the clinical staging and lesion invasion depth of patients with gastric cancer and can significantly improve the sensitivity of diagnosis.
评估单胃镜、多层螺旋 CT、HER-2 或肿瘤标志物及其联合诊断胃癌的诊断准确性。
选取 98 例胃癌患者为研究对象。所有患者均行术前胃镜、MSCT 检查，检测 HER-2、CEA、CA199、CA724、CA242 表达水平。选取同期 98 例健康成年人作为对照组，比较胃癌发病的危险因素，并对数据进行分析。
5 种标志物在肿瘤大小方面的表达有统计学意义（P＜0.05），但在其他临床资料方面无统计学意义（P＞0.05）。胃癌患者胃黏膜组织中肿瘤标志物 CEA 对胃癌的阳性检出率最高，与胃镜、MSCT 及其他标志物比较差异有统计学意义（P＜0.05）。联合诊断对胃癌分期的灵敏度、特异度、准确度均高于单项诊断，差异有统计学意义（P＜0.05）。与健康成年人比较，胃癌患者在饮食、体质量指数、家族遗传史方面比较差异有统计学意义（P＜0.05），而在是否为 A 型血方面比较差异无统计学意义（P＞0.05）。
胃镜、MSCT、免疫组化标志物 Her-2 及肿瘤标志物 CEA、CA199、CA724、CA242 联合诊断可更准确地判断胃癌患者的临床分期和病变侵袭深度，显著提高诊断的灵敏度。
