来自沈克明的三种新型四氢苯并呋喃衍生物及其细胞毒性活性。

Three new tetrahydrobenzofuran derivatives from K.M.Shen and their cytotoxic activities.

作者信息

Yi Xianguo, Li Zhili, Zheng Quanfang, Sang Ruijuan, Li Haili, Gao Ge, Qin Qingming, Zhu Nailiang

机构信息

Pharmacetical Engineering, Xinyang Agricultural and Forestry University, Xinyang, Henan Province, China.

Animal Husbandry and Veterinary Research Institute, Henan Academy of Agricultural Sciences, Zhengzhou, Henan Province, China.

出版信息

Nat Prod Res. 2023 Oct-Nov;37(20):3369-3373. doi: 10.1080/14786419.2022.2075361. Epub 2022 May 12.

DOI:10.1080/14786419.2022.2075361

PMID:35546105

Abstract

Phytochemical investigation the resins of K.M.Shen yielded three new tetrahydrobenzofuran derivatives named as A-C (). The structures of the new compounds were elucidated by analysis of their NMR, HRMS, and ECD spectra, and the absolute configurations were established through the comparison of experimental and calculated ECD spectra. Compound exhibited moderate antitumor activities against AGS cancer cell with IC values of 15.6 µM. Moreover, assays demonstrated that compound could induce AGS cancer cell apoptosis.

摘要

对K.M. Shen的树脂进行植物化学研究，得到了三种新的四氢苯并呋喃衍生物，命名为A - C（）。通过对其核磁共振（NMR）、高分辨质谱（HRMS）和电子圆二色谱（ECD）光谱的分析阐明了新化合物的结构，并通过实验和计算的ECD光谱比较确定了绝对构型。化合物对AGS癌细胞表现出中等抗肿瘤活性，IC值为15.6 μM。此外，实验表明化合物可诱导AGS癌细胞凋亡。