Li Guangzhi, Li Xiaojin, Cao Li, Shen Liangang, Zhu Jun, Zhang Jing, Wang Junchi, Zhang Lijing, Si Jianyong
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China.
Xinjiang Institute of Chinese Materia Medica and Ethical Materia Medica, Urumqi 830002, China.
Fitoterapia. 2014 Sep;97:247-52. doi: 10.1016/j.fitote.2014.06.016. Epub 2014 Jun 28.
Two new steroidal esters with an unusual framework, Sinkiangenorin A and B, a new organic acid glycoside, Sinkiangenorin C, and four known lignin compounds were isolated from the seeds of Ferula sinkiangensis. The structures of these compounds were established by spectroscopic analysis and single-crystal X-ray diffraction. All of the isolated compounds were tested against Hela, K562 and AGS human cancer cell lines. Sinkiangenorin C showed cytotoxic activity against AGS cells with an IC50 of 36.9 μM.
从新疆阿魏（Ferula sinkiangensis）种子中分离出两种具有独特骨架的新甾体酯，即新疆阿魏苷元A和B，一种新的有机酸糖苷，新疆阿魏苷元C，以及四种已知的木质素化合物。通过光谱分析和单晶X射线衍射确定了这些化合物的结构。对所有分离出的化合物针对Hela、K562和AGS人癌细胞系进行了测试。新疆阿魏苷元C对AGS细胞显示出细胞毒性活性，IC50为36.9 μM。
