Eskişehir Osmangazi University Central Research Laboratory Application and Research Center, Eskişehir, Turkey.
Vocational Health Services High School, Eskisehir Osmangazi University, Eskisehir, Turkey.
Biofouling. 2022 Apr;38(4):355-366. doi: 10.1080/08927014.2022.2066530. Epub 2022 May 11.
Many biofilm studies have focused on axial biofilms, however biofilms in nature and environment are multi-species. Farnesol is a sesquiterpene alcohol found in many essential oils. This study investigated the effects of farnesol on planktonic cells and biofilms of and . The ultrastructural morphology of farnesol treated cells was evaluated by TEM. According to the XTT results, farnesol caused a significant decrease in metabolic activity and scanning electron microscope images confirmed a reduction in the preformed biofilm as a result of farnesol treatment for single species and biofilms. Although farnesol has less effect on dual species biofilm compared to the single species biofilms, its effect on the dual biofilm was found to be stronger than amphotericin B or ampicillin. Further studies are needed to clarify the role of farnesol on fungal-bacterial biofilms.
许多生物膜研究都集中在轴向生物膜上，然而自然界和环境中的生物膜是多物种的。法呢醇是一种倍半萜醇，存在于许多精油中。本研究调查了法呢醇对浮游细胞和 和 生物膜的影响。用 TEM 评估了法呢醇处理细胞的超微结构形态。根据 XTT 结果，法呢醇导致代谢活性显著下降，扫描电子显微镜图像证实，由于法呢醇处理，单种 和 生物膜的预形成生物膜减少。尽管法呢醇对双物种生物膜的影响小于单物种生物膜，但发现法呢醇对双生物膜的影响强于两性霉素 B 或氨苄西林。需要进一步研究来阐明法呢醇对真菌-细菌生物膜的作用。
