Sun Jifei, Du Zhongming, Ma Yue, Chen Limei, Wang Zhi, Guo Chunlei, Luo Yi, Gao Deqiang, Hong Yang, Zhang Lei, Han Ming, Cao Jiudong, Hou Xiaobing, Xiao Xue, Tian Jing, Yu Xue, Fang Jiliang, Zhao Yanping
Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Front Neurol. 2022 Sep 1;13:922207. doi: 10.3389/fneur.2022.922207. eCollection 2022.
Functional magnetic resonance imaging (fMRI) studies examining differences in the activity of brain networks between the first depressive episode (FDE) and recurrent depressive episode (RDE) are limited. The current study observed and compared the altered functional connectivity (FC) characteristics in the default mode network (DMN), cognitive control network (CCN), and affective network (AN) between the RDE and FDE. In addition, we further investigated the correlation between abnormal FC and clinical symptoms.
We recruited 32 patients with the RDE, 31 patients with the FDE, and 30 healthy controls (HCs). All subjects underwent resting-state fMRI. The seed-based FC method was used to analyze the abnormal brain networks in the DMN, CCN, and AN among the three groups and further explore the correlation between abnormal FC and clinical symptoms.
One-way analysis of variance showed significant differences the FC in the DMN, CCN, and AN among the three groups in the frontal, parietal, temporal, and precuneus lobes and cerebellum. Compared with the RDE group, the FDE group generally showed reduced FC in the DMN, CCN, and AN. Compared with the HC group, the FDE group showed reduced FC in the DMN, CCN, and AN, while the RDE group showed reduced FC only in the DMN and AN. Moreover, the FC in the left posterior cingulate cortices and the right inferior temporal gyrus in the RDE group were positively correlated with the 17-item Hamilton Rating Scale for Depression (HAMD-17), and the FC in the left dorsolateral prefrontal cortices and the right precuneus in the FDE group were negatively correlated with the HAMD-17.
The RDE and FDE groups showed multiple abnormal brain networks. However, the alterations of abnormal FC were more extensive and intensive in the FDE group.
研究首次抑郁发作（FDE）与复发性抑郁发作（RDE）之间脑网络活动差异的功能磁共振成像（fMRI）研究有限。本研究观察并比较了RDE与FDE之间默认模式网络（DMN）、认知控制网络（CCN）和情感网络（AN）中功能连接（FC）特征的改变。此外，我们进一步研究了异常FC与临床症状之间的相关性。
我们招募了32例RDE患者、31例FDE患者和30名健康对照者（HCs）。所有受试者均接受静息态fMRI检查。采用基于种子点的FC方法分析三组中DMN、CCN和AN的异常脑网络，并进一步探讨异常FC与临床症状之间的相关性。
单因素方差分析显示，三组在额叶、顶叶、颞叶、楔前叶和小脑中的DMN、CCN和AN的FC存在显著差异。与RDE组相比，FDE组在DMN、CCN和AN中的FC总体上降低。与HC组相比，FDE组在DMN、CCN和AN中的FC降低，而RDE组仅在DMN和AN中的FC降低。此外，RDE组左侧后扣带回皮质和右侧颞下回的FC与17项汉密尔顿抑郁量表（HAMD-17）呈正相关，FDE组左侧背外侧前额叶皮质和右侧楔前叶的FC与HAMD-17呈负相关。
RDE组和FDE组均显示多个异常脑网络。然而，FDE组异常FC的改变更为广泛和强烈。
