Jasińska-Mikołajczyk Anna, Drews Katarzyna, Domaszewska Katarzyna, Kolasa Grzegorz, Konofalska Marta, Jowik Katarzyna, Skibińska Maria, Rybakowski Filip
Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
Department of Physiology and Biochemistry, Poznan University of Physical Education, Poznan, Poland.
Front Psychiatry. 2022 Apr 25;13:777394. doi: 10.3389/fpsyt.2022.777394. eCollection 2022.
Cognitive deficits occur in most patients with affective disorders. The role of neurotrophic factors (e.g., BDNF) as modulators of brain plasticity affecting neurocognitive abilities has been emphasized. Neurotrophin concentrations may change under the influence of various interventions, including physical activity. Selected studies have shown that cognitive function may also be affected by exercise.
The aim of the study was to determine whether physical activity changes the concentration of neurotrophins and their receptors in patients with an episode of depression. It was also examined how one session of aerobic exercise affects cognitive control.
The study included 41 participants. The subjects were asked to exercise on a cycloergometer for 40 min with individually selected exercise loads (70% VOmax). Before and shortly after the exercise blood samples were acquired to perform blood assays (proBDNF, BDNF, TrkB, NGFR). The participants also performed a Stroop test twice-before the exercise and 10 min after its cessation.
The single bout of physical exercise did not cause any significant changes in the concentration of neurotrophic factors. The SCWT results: both the mean reading time (29.3 s vs. 47.8 s) and the color naming time (36.7 s vs. 50.7 s) increased. The patients made more mistakes after physical exercise, both in part A (0.2 vs. 1.5) and B (0.6 vs. 1.5). The so-called interference effect decreased-the difference between naming and reading times was smaller after exercise (6.2 s vs. 2.4 s). No significant correlations were found between the concentrations of the studied neurotrophic factors and the Stroop test results.
The results did not confirm changes in neurotrophin concentration under the influence of a single session of physical activity. The shortening of the interference time after exercise may be caused by practice effects. A significant limitation of the study is the use of the Stroop test twice in short intervals.
大多数情感障碍患者存在认知缺陷。神经营养因子（如脑源性神经营因子，BDNF）作为影响神经认知能力的脑可塑性调节因子的作用已得到强调。神经营养素浓度可能会在包括体育活动在内的各种干预影响下发生变化。部分研究表明，运动也可能影响认知功能。
本研究旨在确定体育活动是否会改变抑郁症发作患者神经营养素及其受体的浓度。同时还研究了一次有氧运动对认知控制的影响。
该研究纳入了41名参与者。受试者被要求在功率自行车上以个体选择的运动负荷（70%最大摄氧量，VOmax）锻炼40分钟。在运动前和运动后不久采集血样以进行血液检测（前体BDNF、BDNF、酪氨酸激酶受体B，TrkB、神经生长因子受体，NGFR）。参与者还在运动前和运动停止后10分钟各进行一次斯特鲁普测试。
单次体育锻炼并未引起神经营养因子浓度的任何显著变化。斯特鲁普颜色词测验（SCWT）结果：平均阅读时间（29.3秒对47.8秒）和颜色命名时间（36.7秒对50.7秒）均增加。运动后患者在A部分（0.2对1.5）和B部分（0.6对1.5）犯的错误更多。所谓的干扰效应降低了——运动后命名和阅读时间之间的差异更小（6.2秒对2.4秒）。在所研究的神经营养因子浓度与斯特鲁普测试结果之间未发现显著相关性。
结果未证实单次体育活动影响下神经营养素浓度的变化。运动后干扰时间的缩短可能是由练习效应引起的。本研究的一个显著局限性是在短时间间隔内两次使用斯特鲁普测试。
