Cai Haiming, Liao Shenquan, Li Juan, Liu Qihong, Luo Shengjun, Lv Minna, Lin Xuhui, Hu Junjing, Zhang Jianfei, Qi Nanshan, Sun Mingfei
Zhaoqing/Maoming Branch Center of Guangdong Laboratory for Lingnan Modern Agricultural Science and Technology, Key Laboratory of Livestock Disease Prevention of Guangdong Province, Key Laboratory of Avian Influenza and Other Major Poultry Diseases Prevention and Control, Ministry of Agriculture and Rural Affairs, Institute of Animal Health, Guangdong Academy of Agricultural Sciences, Guangzhou, China.
Jiangsu HFQ Biotechnology Co., Ltd., Haimen, China.
Front Microbiol. 2022 Apr 25;13:811428. doi: 10.3389/fmicb.2022.811428. eCollection 2022.
Avian coccidiosis is an important intestinal protozoan disease that has caused major economic losses to the poultry industry. can not only maintain the stability of the intestinal barrier, but can also improve the production performance of broiler chickens. We studied the effects of feeding alone, administration of coccidiosis vaccine alone, and the combined administration of and coccidiosis vaccine on body weight gain, feed consumption, and feed conversion ratio of broilers. Meanwhile, intestinal contents of 8- and 15-day-old broilers were collected, and their intestinal microbiome was characterized by high-throughput sequencing of the V3-V4 region of 16S rDNA. We analyzed the oocysts per gram values and lesion scores in the alone group, in a group challenged with the coccidiosis-causing parasite, , and in groups simultaneously challenged and pretreated with , the coccidiosis vaccine, or combined and coccidiosis vaccine. Intestinal tissue samples were collected from 32-day-old broilers for microbiome analysis. Our results showed that combination of with coccidiosis vaccine significantly improved the performance of broiler chickens and also significantly reduced the oocysts per gram value and intestinal lesions caused by sp. infection. Furthermore, and coccidiosis vaccine administered alone or in combination significantly increased the relative abundance of the immune biomarker genus . The significant increase in the abundance of the Clostridia_UCG.014, group and was a key factor in controlling sp. infection.
禽球虫病是一种重要的肠道原生动物疾病，给家禽业造成了重大经济损失。（此处原文似乎缺失关键信息）不仅可以维持肠道屏障的稳定性，还可以提高肉鸡的生产性能。我们研究了单独投喂（此处原文缺失关键信息）、单独接种球虫病疫苗以及同时投喂（此处原文缺失关键信息）和接种球虫病疫苗对肉鸡体重增加、采食量和饲料转化率的影响。同时，收集8日龄和15日龄肉鸡的肠道内容物，通过对16S rDNA的V3-V4区域进行高通量测序来表征其肠道微生物群。我们分析了单独使用（此处原文缺失关键信息）组、用引起球虫病的寄生虫（此处原文缺失关键信息）攻击的组以及同时用（此处原文缺失关键信息）、球虫病疫苗或（此处原文缺失关键信息）与球虫病疫苗联合预处理的组中的每克卵囊值和病变评分。从32日龄肉鸡收集肠道组织样本进行微生物群分析。我们的结果表明，（此处原文缺失关键信息）与球虫病疫苗联合使用显著提高了肉鸡的性能，也显著降低了由（此处原文缺失关键信息）sp.感染引起的每克卵囊值和肠道病变。此外，单独或联合使用（此处原文缺失关键信息）和球虫病疫苗显著增加了免疫生物标志物属（此处原文缺失关键信息）的相对丰度。梭菌属_UCG.014、（此处原文缺失关键信息）组和（此处原文缺失关键信息）丰度的显著增加是控制（此处原文缺失关键信息）sp.感染的关键因素。
