三丁酸甘油酯对球虫病疫苗接种后肉鸡生产性能和肠道健康的影响。

The Impact of Tributyrin on Performance and Intestinal Health of Broiler Chickens Post Coccidiosis Vaccination.

机构信息

State Key Laboratory of Livestock and Poultry Breeding.

Guangdong Key Laboratory of Animal Breeding and Nutrition.

出版信息

Avian Dis. 2021 Sep;65(3):493-499. doi: 10.1637/aviandiseases-D-20-00041.

DOI:10.1637/aviandiseases-D-20-00041

PMID:34699148

Abstract

Coccidiosis is a major intestinal disease affecting broiler chickens. Tributyrin (TB) is a valid alternative to butyrate acid, which was associated with the improvement of performance and attenuation of intestinal inflammation in animal production. However, there are few reports on TB as a prophylactic treatment against coccidiosis in broilers. The aim of the study was to investigate the effects of TB supplementation on performance and intestinal health of broiler chickens post coccidiosis vaccination with a mixed-species . In the first experiment, 612 broiler chicks were randomly assigned to two treatments with six replicates. Treatments included no TB supplementation and coccidiosis vaccination (CV1), or TB supplementation (400 mg/kg) and coccidiosis vaccination (TBCV1). On day 5, all broilers received a single vaccine dose. Performance, intestinal histopathology, clinical severity, and fecal oocyst counts were evaluated from day 1 to day 63. TB supplementation resulted in a nonsignificant effect on body weight gain (BWG), feed intake (FI), and mortality-corrected feed conversion ratio (FCR), except in increased FI on days 22-42 ( < ). The TBCV1 group had increased ( < ) villi heights in the duodenum and increased ( < ) villi widths in the ileum on day 63 of age and reduced oocyst shedding on days 19-26 compared to CV1( < ). The route of administration in the second experiment was different from the first experiment in which the seeder birds (half of birds from each pen) received a tenfold dose on day 5. TB supplementation in broilers resulted in increased ( < ) BWG and reduced ( < ) FCR on days 22-42, and increased ( < ) villi heights in the duodenum and increased ( < ) villi widths in the ileum on day 63 of age, as well as a lower frequency ( < ) of intestinal hemorrhage on days 13-62 and reduced ( < ) oocyst shedding on day 5 post- challenge. In conclusion, the study demonstrated that TB can be considered as a feed additive for protecting broilers from coccidiosis on days 22-42.

摘要

球虫病是一种影响肉鸡的主要肠道疾病。三丁酸甘油酯（TB）是丁酸的有效替代品，它与动物生产中性能的提高和肠道炎症的减轻有关。然而，关于 TB 作为肉鸡球虫病预防治疗的报道很少。本研究旨在研究 TB 补充剂对混合种球虫疫苗接种后肉鸡性能和肠道健康的影响。在第一个实验中，将 612 只肉鸡随机分为两组，每组 6 个重复。处理包括不添加 TB 和球虫病疫苗接种（CV1），或添加 TB（400mg/kg）和球虫病疫苗接种（TBCV1）。第 5 天，所有肉鸡均接受单次疫苗剂量。从第 1 天到第 63 天，评估了体重增加（BWG）、采食量（FI）、死亡率校正饲料转化率（FCR）、肠道组织病理学、临床严重程度和粪便卵囊计数。TB 补充剂对体重增加（BWG）、采食量（FI）和死亡率校正饲料转化率（FCR）没有显著影响，但在第 22-42 天增加了采食量（ < ）。TBCV1 组在第 63 天龄时十二指肠的绒毛高度增加（ < ），空肠的绒毛宽度增加（ < ），并且与 CV1 相比，19-26 天的卵囊脱落减少（ < ）。第二个实验的给药途径与第一个实验不同，即在第 5 天，半只鸡（每笼的一半）接受十倍剂量。TB 补充剂可使肉鸡在第 22-42 天体重增加（ < ），饲料转化率降低（ < ），第 63 天十二指肠绒毛高度增加（ < ），空肠绒毛宽度增加（ < ），第 13-62 天肠道出血频率降低（ < ），第 5 天攻毒后卵囊脱落减少（ < ）。总之，本研究表明，TB 可作为保护肉鸡免受 22-42 天球虫病的饲料添加剂。