Crowell W A, Finco D R, Rawlings C A, Barsanti J A, Rao R N
Vet Pathol. 1987 Mar;24(2):124-8. doi: 10.1177/030098588702400204.
Renal allografts were transplanted into 20 dogs (12 beagles, eight mongrels) following a prescribed protocol for pre-transplantation blood transfusions and kidney exchange. Immunosuppressive therapy (azathioprine and prednisone) was modified as needed for each dog. Seven of the beagle dogs survived for 1 year and were then euthanized; all other dogs died or were euthanized prior to 1 year post-transplantation. Graft rejection and renal failure were the greatest causes of mortality. Renal lesions which contributed to the death of some animals included renal vein thrombosis, nephrosis, and pyelonephritis. Inflammation of the lower respiratory tract (bronchitis, pneumonia, and pleuritis) was a contributory cause of death in some dogs. Cystitis and ureteritis occurred in almost half of the dogs. Prostatitis was seen in six of the 16 male dogs. Adrenal cortical atrophy, parathyroid gland hyperplasia, and bone marrow hypocellularity were seen in a majority of the dogs which survived 1 year.
按照规定的移植前输血和肾脏交换方案，将同种异体肾移植到20只犬（12只比格犬，8只杂种犬）体内。根据每只犬的需要调整免疫抑制治疗（硫唑嘌呤和泼尼松）。7只比格犬存活了1年，然后实施安乐死；所有其他犬在移植后1年内死亡或被实施安乐死。移植物排斥和肾衰竭是最主要的死亡原因。导致一些动物死亡的肾脏病变包括肾静脉血栓形成、肾病和肾盂肾炎。下呼吸道炎症（支气管炎、肺炎和胸膜炎）是一些犬死亡的一个促成因素。几乎一半的犬发生膀胱炎和输尿管炎。16只雄性犬中有6只出现前列腺炎。在存活1年的大多数犬中可见肾上腺皮质萎缩、甲状旁腺增生和骨髓细胞减少。
