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2
Selective Laser Melting of Patient Individualized Osteosynthesis Plates-Digital to Physical Process Chain.患者个体化接骨板的选择性激光熔化——从数字到物理的工艺链
Materials (Basel). 2020 Dec 18;13(24):5786. doi: 10.3390/ma13245786.
3
Rational design, bio-functionalization and biological performance of hybrid additive manufactured titanium implants for orthopaedic applications: A review.用于骨科应用的混合增材制造钛植入物的合理设计、生物功能化及生物学性能:综述
J Mech Behav Biomed Mater. 2020 May;105:103671. doi: 10.1016/j.jmbbm.2020.103671. Epub 2020 Feb 6.
4
Understanding the effects of PBF process parameter interplay on Ti-6Al-4V surface properties.理解 PBF 工艺参数相互作用对 Ti-6Al-4V 表面性能的影响。
PLoS One. 2019 Aug 29;14(8):e0221198. doi: 10.1371/journal.pone.0221198. eCollection 2019.
5
Effect of Hatch Spacing on Melt Pool and As-built Quality During Selective Laser Melting of Stainless Steel: Modeling and Experimental Approaches.孵化间距对不锈钢选择性激光熔化过程中熔池和成型质量的影响:建模与实验方法
Materials (Basel). 2018 Dec 24;12(1):50. doi: 10.3390/ma12010050.
6
Biocompatibility of Advanced Manufactured Titanium Implants-A Review.先进制造钛植入物的生物相容性——综述
Materials (Basel). 2014 Dec 19;7(12):8168-8188. doi: 10.3390/ma7128168.

基于物理力学性能和生物学评价的激光粉末床熔融打印Ti6Al4V合金定制型骨科植入物的参数优化

Parameter Optimization for Printing Ti6Al4V-Alloy Patient-Customized Orthopaedic Implants by Laser Powder Bed Fusion Using Physio-mechanical Properties and Biological Evaluations.

作者信息

Gaur Bhanupratap, Ghyar Rupesh, Bhallamudi Ravi

机构信息

Biomedical Engineering and Technology Innovation Centre (BETIC) Lab, Mechanical Engineering Department, Indian Institute of Technology Bombay, Powai, Mumbai, Maharashtra 400076 India.

出版信息

Indian J Orthop. 2021 Dec 2;56(5):797-804. doi: 10.1007/s43465-021-00577-1. eCollection 2022 May.

DOI:10.1007/s43465-021-00577-1
PMID:35547343
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9043156/
Abstract

BACKGROUND

A class of additive manufacturing technologies called Laser powder bed fusion (LPBF), which allows fabricating metallic components with complex geometries in near-net-shape, can be employed for fabricating patient-customized orthopaedic implants. Selection and optimization of the LPBF process parameters are critical to achieving the required biomechanical properties and fabricability of such implants.

METHODS

The process parameters of direct metal laser sintering, the most widely used LPBF process, were optimized for fabricating Ti6Al4V ELI orthopaedic implants, based on ASTM and ASM standards. The parameters included Laser power, Laser velocity and hatch distance, which were varied using Taguchi approach. A multi-criteria decision-making technique (TOPSIS) was employed to optimize the process parameters considering yield and ultimate tensile strength, percentage elongation, part density, volumetric energy density and printing time. In-vitro cytotoxicity and in-vivo muscle implantation were performed on the optimized samples for determining the suitability of the parameters for biomedical applications.

RESULTS

A combination of medium laser power, higher laser velocity, and lower hatch distance with values 200 W, 2200 mm/s and 0.08 mm, respectively, was found to be suitable for producing implants. Based on the type of LPBF technology in use, an implant manufacturer can select the initial set of parameters using a similar approach and improve them further based on experimental results.

CONCLUSION

The optimized parameters were found to be suitable for developing orthopaedic implants, in terms of physical, mechanical and biological criteria. The methods and results presented in work are expected to assist the implant manufacturers in meeting the expected user requirements and quality standards.

摘要

背景

一类名为激光粉末床熔融(LPBF)的增材制造技术能够制造出接近最终形状的具有复杂几何形状的金属部件,可用于制造患者定制的骨科植入物。LPBF工艺参数的选择和优化对于实现此类植入物所需的生物力学性能和可制造性至关重要。

方法

基于ASTM和ASM标准,对最广泛使用的LPBF工艺——直接金属激光烧结的工艺参数进行优化,以制造Ti6Al4V ELI骨科植入物。这些参数包括激光功率、激光速度和扫描间距,采用田口方法对其进行变化。采用多准则决策技术(TOPSIS),综合屈服强度、极限抗拉强度、伸长率、零件密度、体积能量密度和打印时间等因素对工艺参数进行优化。对优化后的样品进行体外细胞毒性和体内肌肉植入实验,以确定这些参数在生物医学应用中的适用性。

结果

发现分别采用200W、2200mm/s和0.08mm的中等激光功率、较高激光速度和较低扫描间距的组合适合制造植入物。基于所使用的LPBF技术类型,植入物制造商可以采用类似方法选择初始参数集,并根据实验结果进一步改进。

结论

从物理、机械和生物学标准来看,优化后的参数适合用于开发骨科植入物。本文所展示的方法和结果有望帮助植入物制造商满足预期的用户需求和质量标准。