Li Xiaoming, Yao Qiandong, Liu Chen, Wang Jian, Zhang Huarong, Li Shiguang, Cai Ping
Department of Radiology, Southwest Hospital, Third Military Medical University (Army Military Medical University), Chongqing, People's Republic of China.
Department of Radiology, The First People's Hospital of Zunyi, The Third Affiliated Hospital of Zunyi Medical University, Zunyi, People's Republic of China.
J Hepatocell Carcinoma. 2022 May 5;9:379-387. doi: 10.2147/JHC.S364742. eCollection 2022.
Hepatocellular carcinoma is one of the most common malignancies globally. Recently, a newly identified histological subtype, designated as "macrotrabecular-massive hepatocellular carcinoma" (MTM-HCC), has been associated with an aggressive phenotype and has received extensive attention. MTM-HCC was a strong independent prognostic predictor of early and overall recurrence because it is closely related to tumor molecular subclass, gene mutation, carcinogenesis pathways, and immunohistochemical markers. In addition, preoperative imaging examination can potentially provide an essential clue for diagnosing MTM-HCC, intratumor necrosis or ischemia is an independent predictor for MTM-HCC on Gd-EOB-DTPA enhanced MRI or CT. Early diagnosis and appropriate treatment of MTM-HCC could prove beneficial for preventing early recurrence and could improve outcomes.
肝细胞癌是全球最常见的恶性肿瘤之一。最近，一种新发现的组织学亚型，被命名为“大小梁-大块肝细胞癌”（MTM-HCC），与侵袭性表型相关并受到广泛关注。MTM-HCC是早期和总体复发的强有力独立预后预测指标，因为它与肿瘤分子亚类、基因突变、致癌途径和免疫组化标志物密切相关。此外，术前影像学检查有可能为MTM-HCC的诊断提供重要线索，肿瘤内坏死或缺血是Gd-EOB-DTPA增强MRI或CT上MTM-HCC的独立预测指标。MTM-HCC的早期诊断和适当治疗可能有利于预防早期复发并改善预后。
