Marković Zoran M, Jovanović Svetlana P, Mašković Pavle Z, Danko Martin, Mičušík Matej, Pavlović Vladimir B, Milivojević Dušan D, Kleinová Angela, Špitalský Zdeno, Todorović Marković Biljana M
Polymer Institute, Slovak Academy of Sciences Dubravska Cesta 9 84541 Bratislava Slovakia
Vinča Institute of Nuclear Sciences, University of Belgrade P.O.B. 522 11001 Belgrade Serbia
RSC Adv. 2018 Sep 5;8(55):31337-31347. doi: 10.1039/c8ra04664f.
Due to controversial reports concerning antibacterial activity of different graphene based materials it is very important to investigate their antibacterial action on a wide range of Gram-positive and Gram-negative bacteria. In this paper we have investigated the structure induced phototoxic antibacterial activity of four types of graphene based materials: graphene oxide (GO), graphene quantum dots (GQDs), carbon quantum dots (CQDs) and nitrogen doped carbon quantum dots (N-CQDs). Antibacterial activity was tested on 19 types of bacteria. It is found that nanometer-size CQDs and N-CQDs are the most potent agents whereas micrometer-size GO has very poor antibacterial activity. Electron paramagnetic resonance measurements confirmed photodynamic production of singlet oxygen for all types of used quantum dots. Detailed analysis has shown that N-CQDs are an excellent photodynamic antibacterial agent for treatment of bacterial infections induced by (), (), (), (), () and .
由于关于不同石墨烯基材料抗菌活性的报道存在争议，因此研究它们对多种革兰氏阳性菌和革兰氏阴性菌的抗菌作用非常重要。在本文中，我们研究了四种石墨烯基材料的结构诱导光毒性抗菌活性：氧化石墨烯（GO）、石墨烯量子点（GQD）、碳量子点（CQD）和氮掺杂碳量子点（N-CQD）。对19种细菌进行了抗菌活性测试。发现纳米尺寸的CQD和N-CQD是最有效的抗菌剂，而微米尺寸的GO抗菌活性很差。电子顺磁共振测量证实了所有类型的所用量子点都会光动力产生单线态氧。详细分析表明，N-CQD是一种出色的光动力抗菌剂，可用于治疗由（）、（）、（）、（）、（）和引起的细菌感染。
