Marković Zoran M, Milivojević Dušan D, Kovač Janez, Todorović Marković Biljana M
Vinča Institute of Nuclear Sciences, National Institute of the Republic of Serbia, University of Belgrade, 11158 Belgrade, Serbia.
Department of Surface Engineering, Jozef Stefan Institute, Jamova 39, SI-1000 Ljubljana, Slovenia.
Polymers (Basel). 2024 Jun 11;16(12):1646. doi: 10.3390/polym16121646.
Nowadays, bacteria resistance to many antibiotics is a huge problem, especially in clinics and other parts of the healthcare system. This critical health issue requires a dynamic approach to produce new types of antibacterial coatings to combat various pathogen microbes. In this research, we prepared a new type of carbon quantum dots based on phloroglucinol using the bottom-up method. Polyurethane composite films were produced using the swell-encapsulation-shrink method. Detailed electrostatic force and viscoelastic microscopy of carbon quantum dots revealed inhomogeneous structure characterized by electron-rich/soft and electron-poor/hard regions. The uncommon photoluminescence spectrum of carbon quantum dots core had a multipeak structure. Several tests confirmed that carbon quantum dots and composite films produced singlet oxygen. Antibacterial and antibiofouling efficiency of composite films was tested on eight bacteria strains and three bacteria biofilms.
如今，细菌对许多抗生素产生耐药性是一个巨大的问题，尤其是在诊所和医疗系统的其他部门。这个关键的健康问题需要一种动态的方法来生产新型抗菌涂层，以对抗各种致病微生物。在本研究中，我们采用自下而上的方法制备了一种基于间苯三酚的新型碳量子点。采用溶胀-封装-收缩法制备了聚氨酯复合薄膜。对碳量子点进行的详细静电力和粘弹性显微镜观察显示，其结构不均匀，具有富电子/软区和贫电子/硬区的特征。碳量子点核心不寻常的光致发光光谱具有多峰结构。多项测试证实，碳量子点和复合薄膜产生了单线态氧。在八种细菌菌株和三种细菌生物膜上测试了复合薄膜的抗菌和抗生物污损效率。
