Anto Michel Nathaly, Ljubojevic-Holzer Senka, Bugger Heiko, Zirlik Andreas
University Heart Center Graz, Department of Cardiology, Medical University of Graz, Graz, Austria.
Front Cardiovasc Med. 2022 Apr 25;9:868466. doi: 10.3389/fcvm.2022.868466. eCollection 2022.
Recent advances in technology such as the introduction of high throughput multidimensional tools like single cell sequencing help to characterize the cellular composition of the human heart. The diversity of cell types that has been uncovered by such approaches is by far greater than ever expected before. Accurate identification of the cellular variety and dynamics will not only facilitate a much deeper understanding of cardiac physiology but also provide important insights into mechanisms underlying its pathological transformation. Distinct cellular patterns of cardiac cell clusters may allow differentiation between a healthy heart and a sick heart while potentially predicting future disease at much earlier stages than currently possible. These advances have already extensively improved and will ultimately revolutionize our knowledge of the mechanisms underlying cardiovascular disease as such. In this review, we will provide an overview of the cells present in the human and rodent heart as well as genes that may be used for their identification.
技术上的最新进展，如引入高通量多维工具（如单细胞测序），有助于描绘人类心脏的细胞组成。通过此类方法揭示的细胞类型多样性，远比以往预期的要多得多。准确识别细胞种类和动态变化，不仅有助于更深入地理解心脏生理学，还能为其病理转变的潜在机制提供重要见解。心脏细胞簇独特的细胞模式，或许能区分健康心脏和患病心脏，同时有可能在比目前更早的阶段预测未来疾病。这些进展已经在很大程度上改进了我们对心血管疾病潜在机制的认识，并且最终将彻底改变这方面的知识。在本综述中，我们将概述人类和啮齿动物心脏中存在的细胞以及可用于识别这些细胞的基因。
