由β-酮酰胺高效且多样化地合成多官能化2-吡啶酮。
Efficient and divergent synthesis of polyfunctionalized 2-pyridones from β-keto amides.
作者信息
Gao Baochang, Sun Yufeng, Wang Jun, Yuan Zhigang, Zu Liwu, Zhang Xu, Liu Wenbin
机构信息
Institute of Composite Materials, Key Laboratory of Superlight Material and Surface Technology of Ministry of Education, College of Materials Science and Chemical Engineering, Harbin Engineering University Harbin 150001 P. R. China
Daqing Branch of Heilongjiang Academy of Sciences Daqing 163319 P. R. China.
出版信息
RSC Adv. 2018 Oct 1;8(59):33625-33630. doi: 10.1039/c8ra05709e. eCollection 2018 Sep 28.
Efficient and divergent one-pot synthesis of polyfunctionalized 2-pyridones from β-keto amides based on reaction condition selection was developed. The methodology offers several significant advantages including mild conditions, ease of handling, high yields, and a relatively broad range of substrates. Based on various experiments and observations, a plausible mechanism for the selective synthesis of 2-pyridones was proposed.
基于反应条件的选择，开发了一种从β-酮酰胺高效、多样的一锅法合成多官能化2-吡啶酮的方法。该方法具有几个显著优点，包括反应条件温和、易于操作、产率高以及底物范围相对较广。基于各种实验和观察结果，提出了一种选择性合成2-吡啶酮的合理机制。
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