Liang Meng, Liu Zheng, Zhang Rui, Yang Ji-Hong, Wang Xiao-Wei, Zhang Nan
Department of Hepatobiliary Surgery, Affiliated Hospital of Hebei University, Baoding, China.
Department of Gastroenterology, Affiliated Hospital of Hebei University, Baoding, China.
Front Microbiol. 2025 Sep 1;16:1619323. doi: 10.3389/fmicb.2025.1619323. eCollection 2025.
Pancreatic cancer (PC) is a highly aggressive malignancy with an asymptomatic early stage, often resulting in rapid invasion of adjacent tissues and organs and a high mortality rate. Recent research has increasingly examined the gut microbiome as a potential factor in PC pathogenesis. Although changes in gut microbiota composition have been reported in patients with PC, a comprehensive evaluation of the relationship between gut microbiota and PC has not been systematically conducted.
A systematic search of PubMed, Web of Science, Embase, and Cochrane databases was conducted, and a meta-analysis was performed on 10 studies including a total of 324 patients with PC.
The meta-analysis did not identify a statistically significant difference in -diversity and microbial richness between patients with PC and those in the control group. However, a decrease in , , , , and was observed in patients with PC, while , , , , and levels were increased.
This meta-analysis demonstrates an association between PC and changes in gut microbiota composition at both the species and genus levels.
https://www.crd.york.ac.uk/PROSPERO/recorddashboard, identifier CRD42023468159.
胰腺癌（PC）是一种具有高度侵袭性的恶性肿瘤，早期通常无症状，常导致对邻近组织和器官的快速侵袭，死亡率很高。最近的研究越来越多地将肠道微生物群视为胰腺癌发病机制中的一个潜在因素。尽管已有报道称胰腺癌患者的肠道微生物群组成发生了变化，但尚未系统地全面评估肠道微生物群与胰腺癌之间的关系。
对PubMed、Web of Science、Embase和Cochrane数据库进行了系统检索，并对10项研究（共324例胰腺癌患者）进行了荟萃分析。
荟萃分析未发现胰腺癌患者与对照组之间在α多样性和微生物丰富度上存在统计学显著差异。然而，观察到胰腺癌患者的[具体指标1]、[具体指标2]、[具体指标3]、[具体指标4]和[具体指标5]降低，而[具体指标6]、[具体指标7]、[具体指标8]、[具体指标9]和[具体指标10]水平升高。
这项荟萃分析表明胰腺癌与物种和属水平上的肠道微生物群组成变化之间存在关联。
https://www.crd.york.ac.uk/PROSPERO/recorddashboard，标识符CRD42023468159。
